ArticleScientific reports2023
In vivo hepatic flow distribution by computational fluid dynamics can predict pulmonary flow distribution in patients with Fontan circulation.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 6 citations in OpenAlex.
- A Translational Paradigm for Univentricular Heart Disease: Single-Stage Neonatal Repair with Adaptive Control of Cavopulmonary Flow.Cardiovascular engineering and technology · 2026Article
- Evaluation of neo-innominate connection in bilateral bidirectional Glenn patients using computational flow modeling.JTCVS structural and endovascular · 2026Article
- Artificial intelligence, extended reality and computational modelling in cross-sectional cardiovascular imaging in congenital heart disease: a narrative review.Cardiovascular diagnosis and therapy · 2026Review
- Selection of revision technique for suboptimal total cavopulmonary connection based on computational fluid dynamics: a case report.Journal of cardiothoracic surgery · 2026Article
- Significance of Reynolds Number Consistency in Non-Newtonian Hemodynamic Simulations: Insights from Fontan Circulation.Physics of fluids (Woodbury, N.Y. : 1994) · 2025Article
- Biomechanics and clinical implications of Fontan upsizing.Computers in biology and medicine · 2024Article
- The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation.Physics of fluids (Woodbury, N.Y. : 1994) · 2024Article
- Impact of Age-Related Change in Caval Flow Ratio on Hepatic Flow Distribution in the Fontan Circulation.Circulation. Cardiovascular imaging · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Fontan patients, a lung deprived of hepatic blood may develop pulmonary arterio-venous malformations (PAVMs) resulting in shunting, reduced pulmonary vascular resistance (PVR) and decreased oxygenation. To provide guidance for corrective invasive interventions, we aimed to non-invasively determine how the hepatic to pulmonary blood flow balance correlates with pulmonary flow, PVR, and with oxygen saturation. Magnetic resonance imaging (MRI) data from eighteen Fontan patients (eight females, age 3-14 years) was used to construct patient-specific computational fluid dynamics (CFD) models to calculate the hepatic to pulmonary blood flow. This was correlated with pulmonary vein flow, simulated PVR and oxygen saturation. Clinical applicability of the findings was demonstrated with an interventional patient case. The hepatic to pulmonary blood flow balance correlated with right/left pulmonary vein flow (R
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Registered trials
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