ArticleNature communications2023
Enhanced brain structure-function tethering in transmodal cortex revealed by high-frequency eigenmodes.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Transcriptional correlates of structure-function coupling plasticity in trigeminal neuralgia: unveiling the synaptic and metabolic associations.The journal of headache and pain · 2026Article
- Impaired regional structure-function coupling as novel neurophenotype: mechanistic insights and diagnostic exploration in treatment-resistant depression.Npj mental health research · 2026Article
- Decoupling of neurophysiological activity from structure mirrors global microarchitectural and neuromodulatory trends.Communications biology · 2026Article
- Superficial white matter microstructural impairments correlate with functional alterations and disease severity in early-stage amyotrophic lateral sclerosis.La Radiologia medica · 2026Article
- Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Impact of visual impairment severity on working memory and executive function in children and adolescents.Frontiers in psychology · 2026Article
- Connectome-constrained ligand-receptor interaction analysis for understanding brain network communication.Nature communications · 2025Article
- Counterfactual explanations of tree based ensemble models for brain disease analysis with structure function coupling.Scientific reports · 2025Article
- Structure-function coupling and decoupling during movie watching and resting state: Novel insights bridging EEG and structural imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Network topological reorganization mechanisms of primary visual cortex under multimodal stimulation.Frontiers in neuroscience · 2025Article
- Disruption of structural connectome hierarchy in age-related hearing loss.Frontiers in neuroscience · 2025Article
- Comparing structure-function relationships in brain networks using EEG and fNIRS.Scientific reports · 2024Article
- Contracted functional connectivity profiles in autism.Molecular autism · 2024Article
- Connectome spectrum electromagnetic tomography: A method to reconstruct electrical brain source networks at high-spatial resolution.Human brain mapping · 2024Article
- Altered asymmetry of functional connectome gradients in major depressive disorder.Frontiers in neuroscience · 2024Article
- Eigenmode-based approach reveals a decline in brain structure-function liberality across the human lifespan.Communications biology · 2023Article
- Enhanced brain structure-function tethering in transmodal cortex revealed by high-frequency eigenmodes.Nature communications · 2023Article
- Noise improves the association between effects of local stimulation and structural degree of brain networks.PLoS computational biology · 2023Article
- The shared neurobiological basis of developmental dyslexia and developmental stuttering: A meta-analysis of functional and structural MRI studies.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the link between brain structure and function remains an ongoing challenge, the prevailing hypothesis is that the structure-function relationship may itself be gradually decoupling from unimodal to transmodal cortex. However, this hypothesis is constrained by the underlying models which may neglect requisite information. Here we relate structural and functional connectivity derived from diffusion and functional MRI through orthogonal eigenmodes governing frequency-specific diffusion patterns. We find that low-frequency eigenmodes contribute little to functional interactions in transmodal cortex, resulting in divergent structure-function relationships. Conversely, high-frequency eigenmodes predominantly support neuronal coactivation patterns in these areas, inducing structure-function convergence along a unimodal-transmodal hierarchy. High-frequency information, although weak and scattered, could enhance the structure-function tethering, especially in transmodal association cortices. Our findings suggest that the structure-function decoupling may not be an intrinsic property of brain organization, but can be narrowed through multiplexed and regionally specialized spatiotemporal propagation regimes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.