[Rational design of high performance metal organic framework stationary phase for gas chromatography].

Metal organic frameworks (MOFs) are assembled from metal ions or clusters and organic ligands. The high tunability of these components offers a solid structural foundation for achieving efficient gas chromatography (GC) separation. This review demonstrates that the design of high performance MOFs with suitable stationarity should consider both the thermodynamic interactions provided by these MOFs and the kinetic diffusion of analytes. Thermodynamic parameters are basic indicators for describing the interactions between various analytes and the stationary phase. Thermodynamic parameters such as retention factors, McReynolds constants, enthalpy changes, and entropy changes can reflect the relative intensity of thermodynamic interactions. For example, a larger enthalpy change indicates a stronger thermodynamic interaction between the analytes and stationary phase, whereas a smaller enthalpy change indicates a weaker interaction. In addition, the degree of entropy change reflects the relative degrees of freedom of analytes in the stationary phase. A larger entropy change indicates that the analytes have fewer degrees of freedom in the stationary phase. The higher the degree of restriction, the closer the adsorption of the analytes and, thus, the longer the retention time. Thermodynamic interactions, such as metal affinity,