Evidence map›Paper›PMID 37875357›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2023

Association between gut microbiome and intracerebral hemorrhage based on genome-wide association study data.

Dihui Lin, Xinpeng Liu, Qi Li, Jiabi Qin, Zhendong Xiong, Xinrui Wu

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Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dihui LinDepartment of Public Health and Medical Technology, College of Medicine, Jishou University, Jishou Hunan 416000. ldhdoct@163.com.
Xinpeng LiuDepartment of Public Health and Medical Technology, College of Medicine, Jishou University, Jishou Hunan 416000.
Qi LiXiangxi Tujia and Miao Autonomous Prefecture Center for Disease Prevention and Control, Jishou Hunan 416000.
Jiabi QinDepartment of Epidemic and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410006, China.
Zhendong XiongDepartment of Public Health and Medical Technology, College of Medicine, Jishou University, Jishou Hunan 416000.
Xinrui WuDepartment of Public Health and Medical Technology, College of Medicine, Jishou University, Jishou Hunan 416000. wuxinrui99@qq.com.

Funding

the National Natural Science Foundation 82073653the Natural Science Foundation of Hunan Province 2022JJ10087 and 2022JJ40343the Scientific Research Project of Education Department of Hunan Province 21B0513the Scientific Research Project of Hunan Provincial Health Commission 202212053368the Scientific Research Project of Jishou University Jdx22035
6 · The paper itself

Abstract

objectivesIntracerebral hemorrhage (ICH) has the highest mortality and disability rates among various subtypes of stroke. Previous studies have shown that the gut microbiome (GM) is closely related to the risk factors and pathological basis of ICH. This study aims to explore the causal effect of GM on ICH and the potential mechanisms.

methodsGenome wide association study (GWAS) data on GM and ICH were obtained from Microbiome Genome and International Stroke Genetics Consortium. Based on the GWAS data, we first performed Mendelian randomization (MR) analysis to evaluate the causal association between GM and ICH. Then, a conditional false discovery rate (cFDR) method was conducted to identify the pleiotropic variants.

resultsMR analysis showed that Pasteurellales, Pasteurellaceae, and

conclusionsThere is a causal association and pleiotropic variants between GM and ICH.

Indexed as

Gastrointestinal MicrobiomeStrokeCerebral HemorrhageGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansconditional false discovery rategenome wide association studygut microbiomeintracerebral hemorrhageMendelian randomization

Identifiers

PMID37875357
PMCPMC10930854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.