ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2023
HYPER: pre-clinical device for spatially-confined magnetic particle hyperthermia.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Verification and validation in canine cadaver of an MPI-integrable RF head coil for magnetic particle hyperthermia.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026Article
- Feasibility of thermal dose painting during magnetic nanoparticle thermal therapy: a computational analysis.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026Article
- Design, verification and validation of a spatially confined magnetic nanoparticle thermal therapy device for conformal thermal dose contouring.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026Article
- System-level design trade-offs in magnetic hyperthermia RF instrumentation: a power electronics and electromagnetic design review.Biomedical engineering online · 2026Review
- Verification and Validation of an Autotuning Proportional-Integral-Derivative Controller for Spatially Confined Magnetic Particle Hyperthermia.Journal of medical devices · 2026Article
- Targeted immunotherapies and nanomedicines for ovarian cancer: the way forward.NPJ precision oncology · 2026Review
- Imaging-guided precision hyperthermia with magnetic nanoparticles.Nature reviews bioengineering · 2025Article
- Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers.Small structures · 2025Article
- Ranking Magnetic Colloid Performance for Magnetic Particle Imaging and Magnetic Particle Hyperthermia.Advanced functional materials · 2025Article
- Magnetic particle imaging resolution needed for magnetic hyperthermia treatment planning: a sensitivity analysis.Frontiers in thermal engineering · 2025Article
- Magnetic Particle Imaging-Guided Thermal Simulations for Magnetic Particle Hyperthermia.Nanomaterials (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeMagnetic particle hyperthermia is an approved cancer treatment that harnesses thermal energy generated by magnetic nanoparticles when they are exposed to an alternating magnetic field (AMF). Thermal stress is either directly cytotoxic or increases the susceptibility of cancer cells to standard therapies, such as radiation. As with other thermal therapies, the challenge with nanoparticle hyperthermia is controlling energy delivery. Here, we describe the design and implementation of a prototype pre-clinical device, called HYPER, that achieves spatially confined nanoparticle heating within a user-selected volume and location.
designSpatial control of nanoparticle heating was achieved by placing an AMF generating coil (340 kHz, 0-15 mT), between two opposing permanent magnets. The relative positions between the magnets determined the magnetic field gradient (0.7 T/m-2.3 T/m), which in turn governed the volume of the field free region (FFR) between them (0.8-35 cm VERIFICATION: We verified the performance of the HYPER to design specifications by independently heating two nanoparticle-rich areas of a phantom placed within the volume occupied by the AMF heating coil.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.