Evidence map›Paper›PMID 37875100›Full record

ArticleJournal of breath research2023

A feasibility study on exhaled breath analysis using UV spectroscopy to detect COVID-19.

Saurin R Sutaria, James D Morris, Zhenzhen Xie, Elizabeth A Cooke, Shavonne M Silvers, Grace A Long, Dawn Balcom, Subathra Marimuthu, Leslie W Parrish, Holly Aliesky and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of breath research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Saurin R SutariaDepartments of Chemistry, University of Louisville, Louisville, KY 40292, United States of America.ORCID 0000-0002-2786-2511
James D MorrisChemical Engineering, University of Louisville, Louisville, KY 40292, United States of America.
Zhenzhen XieChemical Engineering, University of Louisville, Louisville, KY 40292, United States of America.
Elizabeth A CookeAnesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Shavonne M SilversAnesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Grace A LongAnesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Dawn BalcomDivision of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Subathra MarimuthuDivision of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Leslie W ParrishDivision of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Holly AlieskyDivision of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Forest W ArnoldDivision of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America.
Jiapeng HuangAnesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America.ORCID 0000-0002-4794-8400
Xiao-An FuChemical Engineering, University of Louisville, Louisville, KY 40292, United States of America.ORCID 0000-0001-6837-6512
Michael H NantzDepartments of Chemistry, University of Louisville, Louisville, KY 40292, United States of America.ORCID 0000-0003-1301-3399
University of Louisville · US

Funding

University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
Low Density Neutrophils Link Inflammation and Coagulopathy in COVID-19R01HL158779 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HUANG, JIAPENG, URIARTE, SILVIA M · 2022 to 2025
$2.9M
Neutrophil Heterogeneity and Immunopathogenesis of COVID-19 ARDSR01AI172873 · NIAID · UNIVERSITY OF LOUISVILLE · PI Jiapeng Huang, Silvia M Uriarte · 2023 to 2026
$2.3M
A Handheld Microchip for GC analysis of breath to screen for COVID-19U18TR003787 · NCATS · UNIVERSITY OF LOUISVILLE · PI FU, XIAO-AN, NANTZ, MICHAEL H · 2021 to 2022
$2.0M
NCATS NIH HHS U18 TR003787NHLBI NIH HHS R01 HL158779NIAID NIH HHS R01 AI172873NIEHS NIH HHS P30 ES030283
6 · The paper itself

Abstract

A 23-subject feasibility study is reported to assess how UV absorbance measurements on exhaled breath samples collected from silicon microreactors can be used to detect COVID-19. The silicon microreactor technology chemoselectively preconcentrates exhaled carbonyl volatile organic compounds and subsequent methanol elution provides samples for analysis. The underlying scientific rationale that viral infection will induce an increase in exhaled carbonyls appears to be supported by the results of the feasibility study. The data indicate statistically significant differences in measured UV absorbance values between healthy and symptomatic COVID-19 positive subjects in the wavelength range from 235 nm to 305 nm. Factors such as subject age were noted as potential confounding variables.

Indexed as

COVID-19Volatile Organic CompoundsBreath TestsExhalationFeasibility StudiesHumansSiliconSpectrum AnalysisSiliconVolatile Organic CompoundsCOVID-19diagnosisexhaled breathpreconcentrationUV spectroscopyVOC

Identifiers

PMID37875100
PMCPMC10620812
OpenAlexW4387899443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.