ArticlePLoS biology2023
Eggs of the mosquito Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism.
Article in PLoS biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Introgression Shapes Genetic Variation Associated With Humid Environments in Aedes aegypti Mosquitoes From Saudi Arabia.Molecular ecology · 2026Article
- Review
- Early photoperiodic cues modulate capacity for adult cold tolerance in the yellow fever mosquito Aedes aegypti.The Journal of experimental biology · 2026Article
- Haplotype-resolved telomere-to-telomere genome ofGenome research · 2026Article
- SkitoSnack 2.0 - A Bloodmeal Alternative for Anopheles and Aedes Mosquitoes.PLoS neglected tropical diseases · 2026Article
- An evaluation of longitudinal Anopheles stephensi egg viability and resistance to desiccation at different thermal conditions over time.Parasites & vectors · 2026Article
- Establishing and sustaining mosquito colonies: insights into morphology, bionomics, and advances in the rearing ofFrontiers in insect science · 2026Review
- The Frontier of Entomo-Virology: Applications and Tools for Virus and Vector Surveillance.Pathogens (Basel, Switzerland) · 2025Review
- Widespread distribution of Aedes aegypti larvae, a potential risk of arbovirus transmission in the Grand Lomé health region, Togo, West Africa.Parasites & vectors · 2025Article
- Interactive Effects of Temperature and Ateleia glazioviana Baill (Fabaceae) Toxicity on Aedes aegypti (Diptera: Culicidae) Mosquito Life-History Traits.Neotropical entomology · 2025Article
- Spatial and temporal analysis of Rift Valley fever outbreaks in livestock in Uganda: a retrospective study from 2013 to 2022.BMC veterinary research · 2025Article
- Decoding prognosis in dengue-induced hepatitis: Model for end-stage liver diseaseWorld journal of gastroenterology · 2025Article
- Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti.Nature ecology & evolution · 2025Article
- Forecasting invasive mosquito abundance in the Basque Country, Spain using machine learning techniques.Parasites & vectors · 2025Article
- Review
- Vertical transmission of Dengue virus type-3 and metagenomic virome profiles of Aedes aegypti mosquitoes collected in Kisumu, Kenya.PloS one · 2025Article
- Alteration of mitochondrial function in arthropods during arboviruses infection: a review of the literature.Frontiers in physiology · 2025Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Upon water loss, some organisms pause their life cycles and escape death. While widespread in microbes, this is less common in animals. Aedes mosquitoes are vectors for viral diseases. Aedes eggs can survive dry environments, but molecular and cellular principles enabling egg survival through desiccation remain unknown. In this report, we find that Aedes aegypti eggs, in contrast to Anopheles stephensi, survive desiccation by acquiring desiccation tolerance at a late developmental stage. We uncover unique proteome and metabolic state changes in Aedes embryos during desiccation that reflect reduced central carbon metabolism, rewiring towards polyamine production, and enhanced lipid utilisation for energy and polyamine synthesis. Using inhibitors targeting these processes in blood-fed mosquitoes that lay eggs, we infer a two-step process of desiccation tolerance in Aedes eggs. The metabolic rewiring towards lipid breakdown and dependent polyamine accumulation confers resistance to desiccation. Furthermore, rapid lipid breakdown is required to fuel energetic requirements upon water reentry to enable larval hatching and survival upon rehydration. This study is fundamental to understanding Aedes embryo survival and in controlling the spread of these mosquitoes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.