Evidence map›Paper›PMID 37874684›Full record

ArticleAging2023

The

Kaiqiang Li, Gabriele Mocciaro, Jules L Griffin, Nianshu Zhang

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kaiqiang LiDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Gabriele MocciaroDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Jules L GriffinDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Nianshu ZhangDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
University of Cambridge · GB

Funding

Medical Research Council MR/P011705/1Wellcome Trust
6 · The paper itself

Abstract

Compared to replicative lifespan, epigenetic regulation of chronological lifespan (CLS) is less well understood in yeast. Here, by screening all the viable mutants of histone acetyltransferase (HAT) and histone deacetylase (HDAC), we demonstrate that Gcn5, functioning in the HAT module of the SAGA/SLIK complex, exhibits an epistatic relationship with the HDAC Hda1 to control the expression of starvation-induced stress response and respiratory cell growth. Surprisingly, the

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAcetylationEpigenesis, GeneticHistone AcetyltransferasesHistone AcetyltransferasesSaccharomyces cerevisiae Proteinsantagonistic pleiotropychronological lifespanGcn5Hda1SAGA

Identifiers

PMID37874684
PMCPMC10637828
OpenAlexW4387873242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.