Evidence map›Paper›PMID 37874643›Full record

ArticleThe Journal of clinical investigation2023

High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases.

Alisa A Mueller, Takanori Sasaki, Joshua W Keegan, Jennifer P Nguyen, Alec Griffith, Alice M Horisberger, Thomas Licata, Elizabeth Fieg, Ye Cao, Mehreen Elahee and 17 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02450851 (Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02450851 recruitingnot on this map

Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network

TypeobservationalSponsorNational Human Genome Research Institute (NHGRI)Ran2015 to 2028Enrolled20,000ConditionsGenetic Disease
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Multi-Omics and Single-Cell Omics: New Tools in Drug Target Discovery.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Alisa A MuellerDepartment of Medicine.
Takanori SasakiDepartment of Medicine.
Joshua W KeeganDepartment of Surgery, and.
Jennifer P NguyenDepartment of Surgery, and.
Alec GriffithDepartment of Surgery, and.
Alice M HorisbergerDepartment of Medicine.
Thomas LicataDepartment of Medicine.
Elizabeth FiegDepartment of Medicine.
Ye CaoDepartment of Medicine.
Mehreen ElaheeDepartment of Medicine.
Kathryne E MarksDepartment of Medicine.
Daimon P SimmonsDepartment of Medicine.
Lauren C BriereCenter for Genomic Medicine.
Laurel A CobbanDepartment of Medicine.
J Carl PallaisDepartment of Medicine.
Frances A HighDepartment of Pediatrics, and.
Melissa A WalkerDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jenny J LinnoilaDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jeffrey A SparksDepartment of Medicine.
V Michael HolersDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Karen H CostenbaderDepartment of Medicine.
Undiagnosed Diseases Network
David A SweetserCenter for Genomic Medicine.
Joel B KrierDepartment of Medicine.
Joseph LoscalzoDepartment of Medicine.
James A LedererDepartment of Surgery, and.
Deepak A RaoDepartment of Medicine.

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6M
Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Coordinating Center for the Undiagnosed Diseases NetworkU01HG007530 · NHGRI · HARVARD MEDICAL SCHOOL · PI KOHANE, ISAAC S. · 2014 to 2022
$30.2M
Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
MECHANISMS OF ARTHRITIC &DERMATOLOGY DISORDERST32AR007530 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner, Ellen M Gravallese · 1986 to 2026
$10.4M
Clinical Sequencing Core Facility for the Undiagnosed Diseases Network (UDN)U01HG007942 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI ENG, CHRISTINE · 2014 to 2021
$10.2M
VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Clinical Genome Wide Sequencing Core for the Undiagnosed Disease NetworkU01HG007943 · NHGRI · MEDICAL COLLEGE OF WISCONSIN · PI WORTHEY, ELIZABETH A · 2014 to 2017
$4.1M
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung DiseaseR01AR077607 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2021 to 2025
$3.7M
Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic DiseasesR01AR080659 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Andrew Sparks · 2023 to 2026
$2.9M
"HSV1-Induced NMDA Receptor Encephalitis: a De Novo Murine Model of Autoimmune Encephalitis"K08NS101084 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LINNOILA, JENNY J · 2017 to 2022
$1.1M
NCATS NIH HHS UL1 TR001102NCI NIH HHS P30 CA006516NHGRI NIH HHS U01 HG007530NHGRI NIH HHS U01 HG007690NHGRI NIH HHS U01 HG007942NHGRI NIH HHS U01 HG007943NIAMS NIH HHS K08 AR072791NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R01 AR077607NIAMS NIH HHS R01 AR080659NIAMS NIH HHS T32 AR007530NINDS NIH HHS K08 NS101084
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Autoimmune DiseasesAutoimmunityHumansImmunophenotypingAutoimmune diseasesAutoimmunityInflammationRheumatology

Identifiers

PMID37874643
PMCPMC10721141

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.