Evidence map›Paper›PMID 37874539›Full record

ArticleJournal of the American Chemical Society2023

Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes.

Richiro Ushimaru, Lide Cha, Shotaro Shimo, Xiaojun Li, Jared C Paris, Takahiro Mori, Kazunori Miyamoto, Lindsay Coffer, Masanobu Uchiyama, Yisong Guo and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Richiro UshimaruGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0002-4071-3326
Lide ChaDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Shotaro ShimoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Xiaojun LiDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Jared C ParisDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0001-9932-5208
Takahiro MoriGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0002-2754-5858
Kazunori MiyamotoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0003-1423-6287
Lindsay CofferDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Masanobu UchiyamaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0001-6385-5944
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-4132-3565
Wei-Chen ChangDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0002-2341-9846
Ikuro AbeGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0002-3640-888X
North Carolina State University · USThe University of Tokyo · JPCarnegie Mellon University · USJapan Science and Technology Agency · JPShinshu University · JP

Funding

Understanding How Nonheme Iron-Dependent Enzymes Assemble Pharmacophores: Studies of Cyclopropane, Aziridine, and Isonitrile FormationR01GM127588 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Wei-chen Chang · 2018 to 2026
$3.3M
NIGMS NIH HHS R01 GM127588
6 · The paper itself

Abstract

BelL and HrmJ are α-ketoglutarate-dependent nonheme iron enzymes that catalyze the oxidative cyclization of 6-nitronorleucine, resulting in the formation of two diastereomeric 3-(2-nitrocyclopropyl)alanine (Ncpa) products containing

Indexed as

AminocaproatesNitro CompoundsOxidation-ReductionStereoisomerismAminocaproatesNitro Compounds(S)-2-amino-6-nitrohexanoic acid

Identifiers

PMID37874539
PMCPMC10725191
OpenAlexW4387892921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.