Evidence map›Paper›PMID 37874484›Full record

ArticleActa parasitologica2023

Microgramma vacciniifolia Frond Lectin: In Vitro Anti-leishmanial Activity and Immunomodulatory Effects Against Internalized Amastigote Forms of Leishmania amazonensis.

Lethícia Maria de Souza Aguiar, Michel Muálem de Moraes Alves, Enoque Pereira Costa Sobrinho Júnior, Patrícia Maria Guedes Paiva, Fernando Aécio de Amorim Carvalho, Lidiane Pereira de Albuquerque, Leydianne Leite de Siqueira Patriota, Thiago Henrique Napoleão

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In one paragraph

Article in Acta parasitologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lethícia Maria de Souza AguiarDepartamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Michel Muálem de Moraes AlvesNúcleo de Pesquisas em Plantas Medicinais-NPPM, Universidade Federal do Piauí, Teresina, Piauí, Brazil.
Enoque Pereira Costa Sobrinho JúniorNúcleo de Pesquisas em Plantas Medicinais-NPPM, Universidade Federal do Piauí, Teresina, Piauí, Brazil.
Patrícia Maria Guedes PaivaDepartamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Fernando Aécio de Amorim CarvalhoNúcleo de Pesquisas em Plantas Medicinais-NPPM, Universidade Federal do Piauí, Teresina, Piauí, Brazil.
Lidiane Pereira de AlbuquerqueDepartamento de Bioquímica e Farmacologia, Universidade Federal do Piauí, Teresina, Piauí, Brazil.
Leydianne Leite de Siqueira PatriotaDepartamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Thiago Henrique NapoleãoDepartamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. thiago.napoleao@ufpe.br.ORCID http://orcid.org/0000-0002-0065-2602
Universidade Federal de Pernambuco · BRUniversidade Federal do Piauí · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 407192/2018-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco APQ-0108-2.08/14Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco APQ-0661-2.08/15
6 · The paper itself

Abstract

purposeThe treatment of leishmaniasis, an anthropozoonosis caused by Leishmania protozoa, is limited by factors, such as adverse effects, toxicity, and excessive cost, which has highlighted the importance of novel drugs. In this context, natural products have been considered as sources of antileishmanial agents. This study investigated the leishmanicidal activity of Microgramma vacciniifolia frond lectin (MvFL) on promastigotes and amastigotes of Leishmania amazonensis.

methodsThe effects of MvFL on promastigote proliferation and macrophage infection by amastigotes were evaluated and mean inhibitory concentrations (IC

resultsAfter 24 h, MvFL inhibited the proliferation of L. amazonensis promastigotes, with an IC

conclusionMvFL exerts antileishmanial activity and further studies are needed to assess its therapeutic potential in in vivo experimental models of leishmaniasis.

Indexed as

Antiprotozoal AgentsLeishmaniaLeishmania mexicanaLeishmaniasisAnimalsHumansLectinsMacrophagesMiceMice, Inbred BALB CAntiprotozoal AgentsLectinsAntileishmanialImmunomodulationLectinMicrogramma vacciniifolia

Identifiers

PMID37874484
OpenAlexW4387892890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.