Evidence map›Paper›PMID 37874459›Full record

ReviewCurrent pain and headache reports2024

Potential Predictors of Response to CGRP Monoclonal Antibodies in Chronic Migraine: Real-World Data.

Carmen Sánchez-Rodríguez, Ana Beatriz Gago-Veiga, David García-Azorín, Ángel Luis Guerrero-Peral, Alicia Gonzalez-Martinez

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Observational
  5. Observational
  6. Psychopathological variables in chronic migraine patients with different therapeutic approach: psychological profile differences and impact on therapeutic efficacy in real life.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carmen Sánchez-RodríguezHeadache Unit, Hospital Universitario de la Princesa & Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Diego de León 62, 28006, Madrid, Spain.
Ana Beatriz Gago-VeigaHeadache Unit, Hospital Universitario de la Princesa & Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Diego de León 62, 28006, Madrid, Spain.ORCID http://orcid.org/0000-0002-0038-3406
David García-AzorínHeadache Unit, Hospital Clínico Universitario de Valladolid & Department of Medicine, University of Valladolid, Valladolid, Spain.ORCID http://orcid.org/0000-0002-3132-1064
Ángel Luis Guerrero-PeralHeadache Unit, Hospital Clínico Universitario de Valladolid & Department of Medicine, University of Valladolid, Valladolid, Spain.ORCID http://orcid.org/0000-0001-7493-6002
Alicia Gonzalez-MartinezHeadache Unit, Hospital Universitario de la Princesa & Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Diego de León 62, 28006, Madrid, Spain. alicia.gonzalez.martinez@live.com.ORCID http://orcid.org/0000-0002-1228-1503

Funding

Instituto de Salud Carlos III CM21/00178Instituto de Salud Carlos III PMP22/00158
6 · The paper itself

Abstract

purpose of reviewReal-world data (RWD) has identified potential predictors of response to anti-CGRP therapies in patients with chronic migraine (CM). This review aims to synthesize the most remarkable findings published to date regarding this topic. RECENT

findingsMigraine features such as unilateral pain and positive triptan response and chronic features such as daily headache or medication overuse (MO) emerge as predictors of positive outcomes, potentially linked to elevated baseline serum anti-calcitonin gene-related peptide (anti-CGRP) levels. Demographic and baseline characteristics, encompassing obesity, psychiatric comorbidities, and prior refractoriness to prophylactic treatments, are associated with poor responses in both treatment-naïve patients and after-switch scenarios. Nevertheless, the consistency of these predictors across diverse populations requires further investigation. Recent RWD literature highlights emerging predictors of response of different sources among patients with CM receiving anti-CGRP therapies. Comprehending these predictors and identifying novel biomarkers of response hold the potential to refine treatment strategies for CM patients, enhancing their management and therapeutic outcomes.

Indexed as

Antibodies, MonoclonalCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsMigraine DisordersBiomarkersChronic DiseaseHumansTreatment OutcomeAntibodies, MonoclonalBiomarkersCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsAnti-CGRPChronicMigrainePredictorsProphylacticResponse

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.