Evidence map›Paper›PMID 37874434›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2023

Variability of cardioinhibition in vasovagal syncope: differences between subgroups during cardioinhibition and beyond.

Ineke A van Rossum, Frederik J de Lange, David G Benditt, Erik W van Zwet, Marc van Houwelingen, Roland D Thijs, J Gert van Dijk

Open access · hybridAbstract read
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Pathophysiological aspects of carotid sinus massage.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  3. Understanding how closed-loop stimulation pacing suppresses cardioinhibition in vasovagal syncope.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Ineke A van RossumDepartment of Neurology, Leiden University Medical Centre, PO Box 9600, 2300, Leiden, The Netherlands. i.a.van_rossum@lumc.nl.ORCID 0000-0002-0999-7156
Frederik J de LangeHeart Centre, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.ORCID 0000-0002-7590-9230
David G BendittCardiac Arrhythmia Center, Cardiovascular Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-8511-6920
Erik W van ZwetDepartment of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0001-5537-3179
Marc van HouwelingenDepartment of Experimental Cardiology, Erasmus Medical Centre, Rotterdam, The Netherlands.ORCID 0009-0002-1885-5835
Roland D ThijsDepartment of Neurology, Leiden University Medical Centre, PO Box 9600, 2300, Leiden, The Netherlands.ORCID 0000-0003-1435-8970
J Gert van DijkDepartment of Neurology, Leiden University Medical Centre, PO Box 9600, 2300, Leiden, The Netherlands.ORCID 0000-0002-6953-7573
Leiden University · NLAmsterdam Neuroscience · NLErasmus University Rotterdam · NLLeiden University Medical Center · NLUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe compared hemodynamic parameters between subjects with marked, intermediate and minimal cardioinhibition during vasovagal syncope.

methodsThe study included subjects with a decrease in heart rate while experiencing a complete vasovagal syncope during tilt-table testing. The subjects were classified as having marked, intermediate or minimal cardioinhibition, based on tertile values of the decrease in heart rate. Hemodynamic parameters between these groups were compared before tilt in the supine position, shortly after tilt and during cardioinhibition.

resultsA total of 149 subjects with a median age of 43 (interquartile range 24-60) years were included in the study. Among the three groups with different levels of cardioinhibition, the highest heart rate was observed in subjects with marked cardioinhibition both before and shortly after tilt and at the start of cardioinhibition. The heart rate decrease in these subjects was both larger and faster compared to subjects with minimal and intermediate cardioinhibition.

conclusionSubjects with marked cardioinhibition have both a larger and faster decrease in heart rate compared to subjects with intermediate and minimal cardioinhibition, as early as from the start of cardioinhibition. Marked cardioinhibition is related to differences in hemodynamic profiles already present well before the start of cardioinhibition.

Indexed as

Syncope, VasovagalAdultHeart RateHemodynamicsHumansMiddle AgedTilt-Table TestTriazolesYoung AdultTriazolesCardioinhibitionReflex syncopeTilt-table testingVasovagal syncope

Identifiers

PMID37874434
PMCPMC10751252
OpenAlexW4387893904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.