Evidence map›Paper›PMID 37874174›Full record

ArticleMicrobiology spectrum2023

Clinically relevant mutations in the PhoR sensor kinase of host-adapted

Juan M Belardinelli, Divya Arora, Charlotte Avanzi, William H Wheat, Josephine M Bryant, John S Spencer, Tom L Blundell, Julian Parkhill, R Andres Floto, Mary Jackson

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. International journal of molecular sciences · 2025
    Review
  5. Article
  6. Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adaptedProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Juan M BelardinelliDepartment of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University , Fort Collins, Colorado, USA.ORCID 0000-0003-1336-9141
Divya AroraDepartment of Medicine, Molecular Immunity Unit, University of Cambridge, MRC-Laboratory of Molecular Biology , Cambridge, United Kingdom.
Charlotte AvanziDepartment of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University , Fort Collins, Colorado, USA.
William H WheatDepartment of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University , Fort Collins, Colorado, USA.
Josephine M BryantDepartment of Medicine, Molecular Immunity Unit, University of Cambridge, MRC-Laboratory of Molecular Biology , Cambridge, United Kingdom.
John S SpencerDepartment of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University , Fort Collins, Colorado, USA.
Tom L BlundellDepartment of Biochemistry, University of Cambridge , Cambridge, United Kingdom.
Julian ParkhillWellcome Sanger Institute , Hinxton, United Kingdom.ORCID 0000-0002-7069-5958
R Andres FlotoDepartment of Medicine, Molecular Immunity Unit, University of Cambridge, MRC-Laboratory of Molecular Biology , Cambridge, United Kingdom.
Mary JacksonDepartment of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University , Fort Collins, Colorado, USA.ORCID 0000-0002-9212-0258
Colorado State University · USMRC Laboratory of Molecular Biology · GBUniversity of Cambridge · GB

Funding

Cystic Fibrosis Foundation (CFF) JACKSO18-G0Cystic Fibrosis Trust (CF) SRC002European Union Horizon 2020 Marie Sklodowska-Curie grant No 845479Vertex Pharmaceuticals Research Innovation Award
6 · The paper itself

Abstract

importanceDifficult-to-treat pulmonary infections caused by nontuberculous mycobacteria of the

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousMycobacterium tuberculosisBacterial ProteinsHost AdaptationHumansHydrogen-Ion ConcentrationMutationProtein KinasesVirulenceBacterial ProteinsPhoR protein, BacteriaProtein Kinasesabscessusacidic pHMycobacteriumphoPRredox homeostasistwo-component response regulator

Identifiers

PMID37874174
PMCPMC10715180
OpenAlexW4387893725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.