Evidence map›Paper›PMID 37874163›Full record

ArticleInfection and immunity2023

Protein-based vaccine candidate MecVax broadly protects against enterotoxigenic

Ipshita Upadhyay, Shafiullah M D Parvej, Yiyang Shen, Siqi Li, Kathryn L Lauder, Chongyang Zhang, Weiping Zhang

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Applied and environmental microbiology · 2026
    Article
  2. Review
  3. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Building a Broader Understanding of EnterotoxigenicOpen forum infectious diseases · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ipshita Upadhyay *Department of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Shafiullah M D Parvej *Department of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Yiyang ShenDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Siqi LiDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Kathryn L LauderDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Chongyang ZhangDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Weiping ZhangDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.ORCID 0000-0002-3723-2257
University of Illinois Urbana-Champaign · US

Funding

Development of MecVax, a Cross Protective Subunit Vaccine for ETECR01AI177144 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WEIPING ZHANG · 2023 to 2026
$4.6M
A cross protective multivalent vaccine for Shigella and ETECR01AI175214 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DAVID A SACK · 2023 to 2026
$3.0M
A broadly protective subunit vaccine against enterotoxigenic Escherichia coli (ETEC) associateddiarrheaR01AI121067 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHANG, WEIPING · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI121067NIAID NIH HHS R01 AI175214NIAID NIH HHS R01 AI177144
6 · The paper itself

Abstract

There are no vaccines licensed against enterotoxigenic

Indexed as

Bacterial ToxinsEnterotoxigenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsEscherichia coli VaccinesAdhesins, BacterialAnimalsAntibodies, BacterialAntigens, BacterialChildDiarrheaEnterotoxinsHumansRabbitsTravelAdhesins, BacterialAntibodies, BacterialAntigens, BacterialBacterial ToxinsEnterotoxinsEscherichia coli ProteinsEscherichia coli Vaccinesbroad protectioncolonizationenterotoxigenic Escherichia coliMecVaxrabbit modelvaccine

Identifiers

PMID37874163
PMCPMC10652908
OpenAlexW4387893019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.