Evidence map›Paper›PMID 37874162›Full record

ArticleInfection and immunity2023

Detoxification of reactive oxygen species by the hyaluronic acid capsule of group A

Shyra Wilde, Ananya Dash, Anders Johnson, Kialani Mackey, Cheryl Y M Okumura, Christopher N LaRock

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Comparing virulence profile of dominantInfectious diseases & immunity · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Pentamidine inhibition of streptopain attenuatesbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shyra WildeMicrobiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University , Atlanta, Georgia, USA.ORCID 0000-0003-4909-5816
Ananya DashImmunology and Molecular Pathogenesis Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University , Atlanta, Georgia, USA.
Anders JohnsonMicrobiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University , Atlanta, Georgia, USA.ORCID 0000-0002-3739-5822
Kialani MackeyDepartment of Biology, Occidental College , Los Angeles, California, USA.
Cheryl Y M OkumuraDepartment of Biology, Occidental College , Los Angeles, California, USA.ORCID 0000-0001-9746-6410
Christopher N LaRockDepartment of Microbiology and Immunology, Emory University School of Medicine , Atlanta, Georgia, USA.ORCID 0000-0003-3035-5331
Emory University · USOccidental College · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5M
Proteolytic regulation of the Streptococcus pyogenes cell surfaceR01AI153071 · NIAID · EMORY UNIVERSITY · PI LAROCK, CHRISTOPHER N · 2021 to 2025
$1.9M
IL-1 regulation of group A Streptococcus infectionK22AI130223 · NIAID · EMORY UNIVERSITY · PI LAROCK, CHRISTOPHER N · 2018 to 2019
$269k
NCATS NIH HHS UL1 TR002378NCI NIH HHS P30 CA138292NIAID NIH HHS K22 AI130223NIAID NIH HHS R01 AI153071
6 · The paper itself

Abstract

The pro-inflammatory cytokine IL-6 regulates antimicrobial responses that are broadly crucial in the defense against infection. Our prior work shows that IL-6 promotes the killing of the M4 serotype group A

Indexed as

Hyaluronic AcidStreptococcal InfectionsAnimalsAntioxidantsBacterial ProteinsInterleukin-6MiceNeutrophilsReactive Oxygen SpeciesStreptococcus pyogenesAntioxidantsBacterial ProteinsHyaluronic AcidInterleukin-6Reactive Oxygen Speciescapsulegroup A Streptococcusinterleukinsoxygen radicalsStreptococcus pyogenes

Identifiers

PMID37874162
PMCPMC10652860
OpenAlexW4387893197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.