Evidence map›Paper›PMID 37874156›Full record

ArticlemSystems2023

Machine-learning analysis of cross-study samples according to the gut microbiome in 12 infant cohorts.

Petri Vänni, Mysore V Tejesvi, Niko Paalanne, Kjersti Aagaard, Gail Ackermann, Carlos A Camargo, Merete Eggesbø, Kohei Hasegawa, Anne G Hoen, Margaret R Karagas and 8 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 6 countries.

Petri VänniResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0003-0100-2545
Mysore V TejesviResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Niko PaalanneResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Kjersti AagaardDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
Gail AckermannDepartment of Pediatrics, University of California, San Diego, California, USA.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Merete EggesbøDepartment of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Kohei HasegawaDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Anne G HoenDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Kaija-Leena KolhoChildren's Hospital, University of Helsinki and HUS, Helsinki, Finland.
Martin F LaursenNational Food Institute, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0001-6017-7121
Johnny LudvigssonCrown Princess Victoria Children's Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Juliette MadanDepartment of Psychiatry, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Dennis OwnbyMedical College of Georgia, Augusta, Georgia, USA.
Catherine StantonTeagasc Food Research Centre & APC Microbiome Ireland, Moorepark, Fermoy, Co. Cork, Ireland.
Jakob StokholmHerlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Terhi TapiainenResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Baylor College of Medicine · USDartmouth College · USHarvard University · USUniversity of Oulu · FIAugusta University · USDartmouth–Hitchcock Medical Center · USLinköping University Hospital · SENorwegian Institute of Public Health · NOOulu University Hospital · FITeagasc - The Irish Agriculture and Food Development Authority · IETechnical University of Denmark · DKUniversity of California San Diego · USUniversity of Copenhagen · DKUniversity of Helsinki · FI

Funding

A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUG3OD023275 · OD · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA, MADAN, JULIETTE · 2016 to 2024
$17.9M
Host genetics, early-life microbiome, and childhood asthma: MARC-43 BostonUH3OD023253 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARLOS ARTURO CAMARGO · 2018 to 2026
$12.1M
Host genetics, early-life microbiome, and childhood asthma: MARC-43 BostonUG3OD023253 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, CARLOS ARTURO · 2016 to 2024
$6.8M
Conserved Fetal Epigenomic Signatures in a Primate Model of Maternal ObesityR01DK089201 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI AAGAARD, KJERSTI MARIE · 2012 to 2021
$5.1M
Source of the Placental MicrobiomeR01HD091731 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI AAGAARD, KJERSTI MARIE · 2017 to 2021
$3.4M
Multi-omic Functional Integration Using NetworksR01LM012723 · NLM · DARTMOUTH COLLEGE · PI HOEN, ANNE GATEWOOD · 2017 to 2020
$1.4M
NICHD NIH HHS R01 HD091731NIDDK NIH HHS R01 DK089201NIH HHS UG3 OD023253NIH HHS UG3 OD023275NIH HHS UH3 OD023253NIH HHS UH3 OD023275NLM NIH HHS R01 LM012723
6 · The paper itself

Abstract

importanceThere are challenges in merging microbiome data from diverse research groups due to the intricate and multifaceted nature of such data. To address this, we utilized a combination of machine-learning (ML) models to analyze 16S sequencing data from a substantial set of gut microbiome samples, sourced from 12 distinct infant cohorts that were gathered prospectively. Our initial focus was on the mode of delivery due to its prior association with changes in infant gut microbiomes. Through ML analysis, we demonstrated the effective merging and comparison of various gut microbiome data sets, facilitating the identification of robust microbiome biomarkers applicable across varied study populations.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaFecesHumansInfantMachine LearningRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbioinformaticschildrencross-studyensemblegut microbiomehuman microbiomeinfantmachine learningrandom forest

Identifiers

PMID37874156
PMCPMC10734493
OpenAlexW4387893424

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.