Evidence map›Paper›PMID 37873898›Full record

ArticlePediatric obesity2023

Changes in leukocyte telomere length among children with obesity participating in a behavioural weight control program.

David H Rehkopf, Janet M Wojcicki, K Farish Haydel, Jue Lin, Dana L Smith, Kristopher I Kapphahn, Thomas N Robinson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

David H RehkopfDepartments of Epidemiology and Population Health, Medicine, Pediatrics and Sociology, Stanford University, Stanford, California, USA.ORCID 0000-0002-7597-6513
Janet M WojcickiDepartments of Pediatrics and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
K Farish HaydelDepartment of Pediatrics, Stanford University, Stanford, California, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA.
Dana L SmithDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA.
Kristopher I KapphahnQuantitative Sciences Unit, Stanford University, Stanford, California, USA.
Thomas N RobinsonDepartments of Pediatrics and Medicine and by courtesy Epidemiology and Population Health, Stanford University, Stanford, California, USA.
University of California, San Francisco · USStanford Health Care · USQuantitative BioSciences · USStanford University · US

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Environmental Strategies & Behavior Change to Reduce Overeating in Obese ChildrenR01HL096015 · NHLBI · STANFORD UNIVERSITY · PI ROBINSON, THOMAS N. · 2010 to 2014
$3.9M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS ULI TR001085NHLBI NIH HHS R01 HL096015
6 · The paper itself

Abstract

objectiveTo examine changes in leukocyte telomere length (LTL) during and after a behavioural weight control program for children with obesity.

methodsWe measured LTL among a cohort of 158 children 8-12 years of age with a body mass index greater than or equal to the 95th percentile for age and sex. Children were 55% female, 29% white, 52% Latinx, 8% Asian and 11% Pacific Islander, other or multiethnic. All children participated in a 6-month, family-based, group behavioural weight control program and were assessed before treatment, after treatment and 1 year after the end of treatment. To test the sample population slope of LTL over the intervention and maintenance time periods, we fit spline mixed-effect regression models.

resultsLTL increased an average of 0.09 T/S units per year (95% confidence interval [CI] 0.04 to 0.13; p = 0.0001) during the weight control program intervention period, followed by an average decline of -0.05 T/S units per year (95% CI -0.08 to -0.03; p < 0.0001) during the 1 year of follow-up after the completion of the intervention. Among 26 social, psychological, behavioural and physiological factors we examined, we did not find any predictors of these changes.

conclusionsLTL increased in response to a behavioural weight control program among children with obesity, suggesting an impact on biological health and cellular aging from participation in a behavioural weight control intervention. LTL may be a useful biomarker for assessing changes in response to behavioural interventions.

Indexed as

LeukocytesObesityBehavior TherapyBody Mass IndexChildFemaleHumansMaleTelomereagingchildhood obesitylifestyle modificationsmolecular mechanisms

Identifiers

PMID37873898
PMCPMC10843039
OpenAlexW4387893875

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.