Evidence map›Paper›PMID 37873772›Full record

ArticleDiseases (Basel, Switzerland)2023

Response Rate of the Third and Fourth Doses of the BNT162b2 Vaccine Administered to Cancer Patients Undergoing Active Anti-Neoplastic Treatments.

Abed Agbarya, Ina Sarel, Tomer Ziv-Baran, Orna Schwartz, Yelena Shechtman, Ella Kozlener, Rasha Khoury, Mohammad Sheikh-Ahmad, Leonard Saiegh, Forat Swaid and 3 more

Open access · goldAbstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Abed AgbaryaBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.ORCID 0000-0002-3330-2959
Ina SarelEdith Wolfson Medical Center, Oncology Institute, Holon 5822012, Israel.
Tomer Ziv-BaranSchool of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.ORCID 0000-0002-2589-8473
Orna SchwartzMicrobiology and Immunology Laboratory, Edith Wolfson Medical Center, Holon 5822012, Israel.
Yelena ShechtmanBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.
Ella KozlenerBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.
Rasha KhouryBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.
Mohammad Sheikh-AhmadBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.
Leonard SaieghBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.ORCID 0000-0001-5771-6569
Forat SwaidBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.
Asala Abu AhmadBnai-Zion Medical Center, Oncology Institute, Haifa 3339419, Israel.
Urska JanzicDepartment of Medical Oncology, University Clinic Golnik, 4202 Golnik, Slovenia.ORCID 0000-0001-9232-1431
Ronen BrennerEdith Wolfson Medical Center, Oncology Institute, Holon 5822012, Israel.
Bnai Zion Medical Center · ILWolfson Medical Center · ILTechnion – Israel Institute of Technology · ILTel Aviv University · ILUniversity Clinic of Pulmonary and Allergic Diseases Golnik · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The BNT162b2 vaccine is globally used for preventing morbidity and mortality related to COVID-19. Cancer patients have had priority for receiving the vaccine due to their diminished immunity. This study reports the response rate of administering the third and fourth vaccine doses to cancer patients receiving active anti-neoplastic treatment. A total of 142 patients received two doses of the mRNA-based BNT162b2 COVID-19 vaccine, while 76 and 25 patients received three and four doses, respectively. The efficacy of the humoral response following two vaccine doses was diminished in cancer patients, especially in the group of patients receiving chemotherapy. In a multivariate analysis, patients who received three and four BNT162b2 vaccine doses were more likely to have antibody titers in the upper tertile compared to patients who received two doses of the vaccine (odds ratio (OR) 7.62 (95% CI 1.38-42.12),

Indexed as

antibodiesanti-neoplastic treatmentBNT162b2 vaccinecancer patientschemotherapyCOVID-19immunocompromisedimmunogenicitySARS-CoV-2

Identifiers

PMID37873772
PMCPMC10594524
OpenAlexW4387105587

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.