Evidence map›Paper›PMID 37873633›Full record

ArticleJournal of Korean medical science2023

Empiric Anti-Pseudomonal β-Lactam Monotherapy Versus Fluoroquinolone Combination Therapy in Patients With Hospital-Acquired Pneumonia: A Multicenter Cohort Study With Propensity Score Matching.

Moon Seong Baek, Ae-Rin Baek, Sang-Bum Hong, Soohyun Bae, Hye Kyeong Park, Changhwan Kim, Hyun-Kyung Lee, Woo Hyun Cho, Jin Hyoung Kim, Youjin Chang and 9 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 15 institutions in 1 country.

Moon Seong BaekDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6455-0376
Ae-Rin BaekDivision of Allergy and Pulmonary Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. aerinbaek@gmail.com.ORCID https://orcid.org/0000-0003-1350-610X
Sang-Bum HongDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2737-7695
Soohyun BaeDepartment of Integrated Internal Medicine, Myoungji Hospital, Hanyang University College of Medicine, Goyang, Korea.ORCID https://orcid.org/0000-0003-3589-0333
Hye Kyeong ParkDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.ORCID https://orcid.org/0000-0002-4634-0401
Changhwan KimDepartment of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0003-3318-2528
Hyun-Kyung LeeDepartment of Internal Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0003-1032-0190
Woo Hyun ChoDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0002-8299-8008
Jin Hyoung KimDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.ORCID https://orcid.org/0000-0002-2229-2388
Youjin ChangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-4838-466X
Heung Bum LeeDepartment of Internal Medicine, Research Center for Pulmonary Disorders, Jeonbuk National University Hospital, Jeonju, Korea.ORCID https://orcid.org/0000-0002-8267-8434
Hyun-Il GilDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1690-8649
Beomsu ShinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.ORCID https://orcid.org/0000-0002-8449-0195
Kwang Ha YooDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-9969-2657
Jae Young MoonDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Chungnam National University College of Medicine, Sejong Hospital, Sejong, Korea.ORCID https://orcid.org/0000-0001-8724-6289
Jee Youn OhDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-1219-0070
Kyung Hoon MinDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-0610-2182
Kyeongman JeonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4822-1772
Korean HAP/VAP Study Group
Inje University Busan Paik Hospital · KRKorea University Medical Center · KRUlsan College · KRChung-Ang University Hospital · KRChungnam National University · KRInje University Ilsan Paik Hospital · KRInje University Sanggye Paik Hospital · KRJeju National University Hospital · KRKangbuk Samsung Hospital · KRKonkuk University · KRMyongji Hospital · KRPusan National University Yangsan Hospital · KRSamsung Medical Center · KRSamsung (South Korea) · KRSoonchunhyang University · KR

Funding

Korea Disease Control and Prevention Agency 2019-E2808-00Soonchunhyang University
6 · The paper itself

Abstract

backgroundThere is insufficient data on the benefits of empiric antibiotic combinations for hospital-acquired pneumonia (HAP). We aimed to investigate whether empiric anti-pseudomonal combination therapy with fluoroquinolones decreases mortality in patients with HAP.

methodsThis multicenter, retrospective cohort study included adult patients admitted to 16 tertiary and general hospitals in Korea between January 1 and December 31, 2019. Patients with risk factors for combination therapy were divided into anti-pseudomonal non-carbapenem β-lactam monotherapy and fluoroquinolone combination therapy groups. Primary outcome was 30-day mortality. Propensity score matching (PSM) was used to reduce selection bias.

resultsIn total, 631 patients with HAP were enrolled. Monotherapy was prescribed in 54.7% (n = 345) of the patients, and combination therapy was prescribed in 45.3% (n = 286). There was no significant difference in 30-day mortality between the two groups (16.8% vs. 18.2%,

conclusionEmpiric anti-pseudomonal fluoroquinolone combination therapy showed no survival benefit compared to β-lactam monotherapy in patients with HAP. Caution is needed regarding the routine combination of fluoroquinolones in the empiric treatment of HAP patients with a high risk of MDR.

Indexed as

Community-Acquired InfectionsPneumoniaAdultAnti-Bacterial Agentsbeta-LactamsDrug Therapy, CombinationFluoroquinolonesHospitalsHumansPropensity ScoreRetrospective StudiesAnti-Bacterial Agentsbeta-LactamsFluoroquinolonesAnti-Bacterial AgentsDrug Resistance, MultipleFluoroquinolonesHealthcare-Associated PneumoniaMortalityPneumonia, Ventilator-Associated

Identifiers

PMID37873633
PMCPMC10593602
OpenAlexW4387695000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.