Evidence map›Paper›PMID 37873566›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.

Nicholas X Russell, Kaulini Burra, Ronak M Shah, Natalia Bottasso-Arias, Megha Mohanakrishnan, John Snowball, Harshavardhana H Ediga, Satish K Madala, Debora Sinner

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Potassium Channels of the Airway Epithelium.Acta physiologica (Oxford, England) · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Nicholas X RussellNeonatology and Pulmonary Biology Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati Honors Program, Cincinnati, Ohio, United States.ORCID 0000-0003-3901-2378
Kaulini BurraNeonatology and Pulmonary Biology Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.ORCID 0000-0002-9107-187X
Ronak M ShahNeonatology and Pulmonary Biology Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati Honors Program, Cincinnati, Ohio, United States.ORCID 0000-0002-3348-2021
Natalia Bottasso-AriasNeonatology and Pulmonary Biology Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.ORCID 0000-0002-3553-6978
Megha MohanakrishnanNeonatology and Pulmonary Biology Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati Honors Program, Cincinnati, Ohio, United States.ORCID 0000-0002-1312-1456
John SnowballNeonatology and Pulmonary Biology Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.ORCID 0000-0001-5267-2085
Harshavardhana H EdigaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.ORCID 0000-0002-2809-5449
Satish K MadalaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.ORCID 0000-0002-6042-5321
Debora SinnerNeonatology and Pulmonary Biology Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, College of Medicine, Cincinnati, Ohio, United States.ORCID 0000-0002-0704-5223
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · US

Funding

WT1 REGULATION OF PULMONARY FIBROSISR01HL134801 · NHLBI · UNIVERSITY OF CINCINNATI · PI MADALA, SATISH K · 2017 to 2025
$3.9M
Sox9 Regulation of Fibroblast Activation and Pulmonary FibrosisR01HL157176 · NHLBI · UNIVERSITY OF CINCINNATI · PI MADALA, SATISH K · 2021 to 2025
$2.5M
Molecular mechanisms underlying trachea formation and the pathology of tracheomalacia and complete tracheal ringsR01HL144774 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SINNER, DEBORA · 2019 to 2023
$2.2M
NHLBI NIH HHS R01 HL134801NHLBI NIH HHS R01 HL144774NHLBI NIH HHS R01 HL157176
6 · The paper itself

Abstract

Ion channels play critical roles in the physiology and function of the nervous system and contractile tissue; however, their role in noncontractile tissue and embryonic development has yet to be understood. Tracheobronchomalacia (TBM) and complete tracheal rings (CTR) are disorders affecting the muscle and cartilage of the trachea and bronchi, whose etiology remains poorly understood. We demonstrated that trachealis muscle organization and polarity are disrupted after epithelial ablation of

Indexed as

TracheaWnt Signaling PathwayAnimalsbeta CateninCartilageMiceMuscle, SmoothPotassium Channelsbeta CateninPotassium Channelscartilagepotassium channelstracheatrachealis muscleWnt

Identifiers

PMID37873566
PMCPMC11068408
OpenAlexW4387893447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.