ArticlebioRxiv : the preprint server for biology2025
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration.
Open access · greenAbstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 8 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 12 institutions in 3 countries.
Silas A BuckDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-9476-9210
Sophie A RubinDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Tenzin KunkhyenDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Christoph D TreiberCentre for Neural Circuits & Behaviour, University of Oxford, Oxford OX1 3TA, UK.ORCID 0000-0002-6994-091X
Xiangning XueDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15232, USA.ORCID 0000-0002-5775-1193
Lief E FennoDepartments of Psychiatry and Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-5237-6179
Samuel J MabryDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-4856-4481
Varun R SundarDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Zilu YangDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Divia ShahDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Kyle D KetchesinDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-2861-5811
Darius D Becker-KrailDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-1751-0598
Iaroslavna VasylievaDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-8932-763X
Megan C SmithDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Florian J WeiselDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-8679-9241
Wenjia WangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15232, USA.
M Quincy Erickson-ObergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Emma I O'LearyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-6437-3848
Eshan AravindDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Charu RamakrishnanDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3474-6332
Yoon Seok KimDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Yanying WuCentre for Neural Circuits & Behaviour, University of Oxford, Oxford OX1 3TA, UK.ORCID 0000-0002-6225-8117
Matthias QuickDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-8620-827X
Jonathan A ColemanDepartment of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
William A MacDonaldDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Rania ElbakriDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Abby L OlsenDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7680-1758
Emily M RochaDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-2171-5104
Gary W MillerDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-8984-1284
Briana R De MirandaCenter for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-8817-327X
Michael J PalladinoDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0002-5923-4771
Brian D McCabeBrain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID 0000-0003-1620-0501
Kenneth N FishDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-1774-3815
Marianne L SeneyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Stephen RayportDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-9755-7486
Susana MingoteDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-0401-4317
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-9440-3967
Thomas S HnaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-6176-8513
Rajeshwar AwatramaniDepartment of Neurology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-0713-2140
Alan M WatsonDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-0632-8296
Scott WaddellCentre for Neural Circuits & Behaviour, University of Oxford, Oxford OX1 3TA, UK.ORCID 0000-0003-4503-6229
Claire E J CheethamDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-4038-1501
Ryan W LoganDepartment of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-8579-015X
Zachary FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6460-0118
University of Pittsburgh · USStanford University · USUniversity of Oxford · GBNew York Psychoanalytic Society and Institute · USColumbia University · USÉcole Polytechnique Fédérale de Lausanne · CHNorthwestern University · USThe Graduate Center, CUNY · USThe University of Texas at Austin · USUniversity of Alabama at Birmingham · USUniversity of California San Diego · USUniversity of Massachusetts Chan Medical School · US
Funding
Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0MCLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERST32MH019986 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Carmen Andreescu · 1997 to 2026
$6.9MTargeting cotransmission for circuit-specific pharmacotherapyR01MH117128 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RAYPORT, STEPHEN · 2018 to 2022
$2.9MNovel roles of VGLUT in sex differences in dopamine neuron vulnerability to environmental toxicant-induced neurodegenerationR01ES034037 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZACHARY FREYBERG · 2023 to 2026
$2.3MSynaptic Actions of Amphetamine in the StriatumR01DA056584 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI STEPHEN RAYPORT · 2023 to 2026
$2.2MCell-type specific role of circadian-dependent transcription in fentanyl-induced synaptic and behavioral plasticity - SupplementR01HL150432 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LOGAN, RYAN W · 2019 to 2020
$2.0MChandelier cell inputs to pyramidal neurons in schizophrenia and developmentR01MH096985 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FISH, KENNETH N · 2012 to 2015
$1.2MHigh-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574kUltra-fast high-resolution imaging of whole mouse brain for the study of drug addictionR21DA052419 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$448kA novel role for midbrain glutamate co-transmitting neurons in alcohol drinking and motivated behaviorsR21AA028800 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$446kMechanisms for Preserving Neurons in Alzheimer's Disease-Related Dementias Across Drosophila and Mouse ModelsR21AG068607 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY · 2020 to 2021
$430kRequest for an Olympus VS200 slide scannerS10MH126905 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FISH, KENNETH N, WATKINS, SIMON C · 2021 to 2021
$370kNHLBI NIH HHS R01 HL150432NIAAA NIH HHS R21 AA028800NIA NIH HHS R21 AG068607NIDA NIH HHS R01 DA056584NIDA NIH HHS R21 DA052419NIEHS NIH HHS R01 ES034037NIH HHS S10 OD028483NIMH NIH HHS R01 MH096985NIMH NIH HHS R01 MH117128NIMH NIH HHS S10 MH126905NIMH NIH HHS T32 MH019986NINDS NIH HHS F31 NS118811NINDS NIH HHS T32 NS007433Wellcome Trust
Abstract
Parkinson's disease (PD) targets some dopamine (DA) neurons more than others. Sex differences offer insights, with females more protected from DA neurodegeneration. The mammalian vesicular glutamate transporter VGLUT2 and
Indexed as
dopamineDrosophiladVGLUTglutamateneurodegenerationparaquatParkinson’s diseaseRNAseqVGLUT2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.