Evidence map›Paper›PMID 37873426›Full record

ArticlebioRxiv : the preprint server for biology2024

Benchmarking AlphaMissense Pathogenicity Predictions Against Cystic Fibrosis Variants.

Eli Fritz McDonald, Kathryn E Oliver, Jonathan P Schlebach, Jens Meiler, Lars Plate

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Eli Fritz McDonaldDepartment of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0002-0572-330X
Kathryn E OliverDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-7781-7006
Jonathan P SchlebachDepartment of Chemistry, Purdue University, West Lafyette, IN 47907, USA.ORCID 0000-0003-0955-7633
Jens MeilerDepartment of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0001-8945-193X
Lars PlateDepartment of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0003-4363-6116
Vanderbilt University · USEmory University · USPurdue University West Lafayette · US

Funding

Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Coordination of chaperone interactions that dictate protein folding and traffickingR35GM133552 · NIGMS · VANDERBILT UNIVERSITY · PI Lars Plate · 2019 to 2026
$3.2M
Rational optimization of combinatorial therapies for the treatment of rare cystic fibrosis variantsR01HL167046 · NHLBI · PURDUE UNIVERSITY · PI Lars Plate, Jonathan Patrick Schlebach · 2023 to 2026
$2.7M
Modulation of ribosome velocity as a means to rescue refractory CF-causing variantsR00HL151965 · NHLBI · EMORY UNIVERSITY · PI OLIVER, KATHRYN E · 2021 to 2023
$747k
Molecular Chaperone Recognition of CFTR StabilityF31HL162483 · NHLBI · VANDERBILT UNIVERSITY · PI MCDONALD, ELI FRITZ · 2022 to 2023
$58k
6 · The paper itself

Abstract

Variants in the cystic fibrosis transmembrane conductance regulator gene (

Identifiers

PMID37873426
PMCPMC10592606
OpenAlexW4387452672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.