Evidence map›Paper›PMID 37873425›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders.

Huifang Xu, Yitang Sun, Michael Francis, Claire F Cheng, Nitya T R Modulla, J Thomas Brenna, Charleston W K Chiang, Kaixiong Ye

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Huifang XuDepartment of Genetics, University of Georgia, Athens, Georgia.
Yitang SunDepartment of Genetics, University of Georgia, Athens, Georgia.
Michael FrancisInstitute of Bioinformatics, University of Georgia, Athens, Georgia.
Claire F ChengDepartment of Genetics, University of Georgia, Athens, Georgia.
Nitya T R ModullaDepartment of Genetics, University of Georgia, Athens, Georgia.
J Thomas BrennaDell Pediatric Research Institute and Department of Pediatrics, The University of Texas at Austin, Texas.
Charleston W K ChiangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.
Kaixiong YeDepartment of Genetics, University of Georgia, Athens, Georgia.
University of Georgia · USThe University of Texas at Austin · USUniversity of Southern California · US

Funding

T32 Predoctoral training grant in geneticsT32GM007103 · NIGMS · UNIVERSITY OF GEORGIA (UGA) · PI DYER, KELLY A · 1985 to 2021
$5.9M
Gene-Environment Interactions in Human Evolution and Complex TraitsR35GM143060 · NIGMS · UNIVERSITY OF GEORGIA · PI YE, KAIXIONG · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM143060NIGMS NIH HHS T32 GM007103
6 · The paper itself

Abstract

The neural tissue is rich in polyunsaturated fatty acids (PUFAs), components that are indispensable for the proper functioning of neurons, such as neurotransmission. PUFA nutritional deficiency and imbalance have been linked to a variety of chronic brain disorders, including major depressive disorder (MDD), anxiety, and anorexia. However, the effects of PUFAs on brain disorders remain inconclusive, and the extent of their shared genetic determinants is largely unknown. Here, we used genome-wide association summary statistics to systematically examine the shared genetic basis between six phenotypes of circulating PUFAs (N = 114,999) and 20 brain disorders (N = 9,725-762,917), infer their potential causal relationships, identify colocalized regions, and pinpoint shared genetic variants. Genetic correlation and polygenic overlap analyses revealed a widespread shared genetic basis for 77 trait pairs between six PUFA phenotypes and 16 brain disorders. Two-sample Mendelian randomization analysis indicated potential causal relationships for 16 pairs of PUFAs and brain disorders, including alcohol consumption, bipolar disorder (BIP), and MDD. Colocalization analysis identified 40 shared loci (13 unique) among six PUFAs and ten brain disorders. Twenty-two unique variants were statistically inferred as candidate shared causal variants, including rs1260326 (

Identifiers

PMID37873425
PMCPMC10593041
OpenAlexW4387330469

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.