Evidence map›Paper›PMID 37873421›Full record

ArticlebioRxiv : the preprint server for biology2023

Chromatinization Modulates Topoisomerase II Processivity.

Jaeyoon Lee, Meiling Wu, James T Inman, Gundeep Singh, Seong Ha Park, Joyce H Lee, Robert M Fulbright, Yifeng Hong, Joshua Jeong, James M Berger and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jaeyoon LeePhysics Department & LASSP, Cornell University, Ithaca, NY 14853, USA.
Meiling WuPhysics Department & LASSP, Cornell University, Ithaca, NY 14853, USA.
James T InmanPhysics Department & LASSP, Cornell University, Ithaca, NY 14853, USA.
Gundeep SinghBiophysics Program, Cornell University, Ithaca, NY 14853, USA.
Seong Ha ParkBiophysics Program, Cornell University, Ithaca, NY 14853, USA.
Joyce H LeeDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Robert M FulbrightPhysics Department & LASSP, Cornell University, Ithaca, NY 14853, USA.
Yifeng HongDepartment of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.
Joshua JeongDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
James M BergerDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Michelle D WangPhysics Department & LASSP, Cornell University, Ithaca, NY 14853, USA.
Cornell University · USJohns Hopkins University · USHoward Hughes Medical Institute · US

Funding

TRAINING IN MOLECULAR PHYSICS OF BIOLOGICAL SYSTEMST32GM008267 · NIGMS · CORNELL UNIVERSITY ITHACA · PI WANG, MICHELLE D. · 1988 to 2021
$9.6M
Structural and Biochemical Analyses of Type II DNA TopoisomerasesR01CA077373 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BERGER, JAMES M. · 1999 to 2021
$7.6M
Understanding and exploiting DNA topoisomerases in cancer biologyR35CA263778 · NCI · JOHNS HOPKINS UNIVERSITY · PI James M. Berger · 2021 to 2026
$5.0M
Fundamental Biological Processes Under TorsionR01GM136894 · NIGMS · CORNELL UNIVERSITY · PI WANG, MICHELLE D. · 2020 to 2023
$1.2M
NCI NIH HHS R01 CA077373NCI NIH HHS R35 CA263778NIGMS NIH HHS R01 GM136894NIGMS NIH HHS T32 GM008267
6 · The paper itself

Abstract

Type IIA topoisomerases are essential DNA processing enzymes that must robustly and reliably relax DNA torsional stress

Identifiers

PMID37873421
PMCPMC10592930
OpenAlexW4387343816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.