Evidence map›Paper›PMID 37873418›Full record

ArticlebioRxiv : the preprint server for biology2024

Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival.

Jongkyun Kang, Guodong Huang, Long Ma, Youren Tong, Anu Shahapal, Phoenix Chen, Jie Shen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jongkyun KangDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Guodong HuangDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Long MaDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Youren TongDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Anu ShahapalDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Phoenix ChenDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Jie ShenDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Brigham and Women's Hospital · US

Funding

LRRK in Autophagy Function and Dopaminergic Neuron SurvivalR37NS071251 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHEN, JIE · 2015 to 2021
$4.5M
NINDS NIH HHS R37 NS071251
6 · The paper itself

Abstract

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease (PD), which is the leading neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). However, whether LRRK2 mutations cause PD and degeneration of DA neurons

Identifiers

PMID37873418
PMCPMC10592668
OpenAlexW4387490770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.