Evidence map›Paper›PMID 37873405›Full record

ArticlebioRxiv : the preprint server for biology2023

TMEM65 regulates NCLX-dependent mitochondrial calcium efflux.

Joanne F Garbincius, Oniel Salik, Henry M Cohen, Carmen Choya-Foces, Adam S Mangold, Angelina D Makhoul, Anna E Schmidt, Dima Y Khalil, Joshua J Doolittle, Anya S Wilkinson and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Joanne F GarbinciusAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Oniel SalikAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Henry M CohenAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Carmen Choya-FocesAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Adam S MangoldAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Angelina D MakhoulAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Anna E SchmidtAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dima Y KhalilAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Joshua J DoolittleAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Anya S WilkinsonAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Emma K MurrayAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Michael P LazaropoulosAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Alycia N HildebrandAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dhanendra TomarAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
John W ElrodAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Temple University · USHospital Universitario Santa Cristina · ESWake Forest University · US

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Douglas Tilley · 2017 to 2026
$21.0M
Targeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2020 to 2024
$11.4M
Integrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5M
Molecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0M
Mitochondria and metabolism in neurodegenerationRF1NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2021 to 2021
$2.3M
Mitochondria and metabolism in neurodegenerationR01NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2024 to 2025
$1.5M
Impact of mitochondrial structure on cellular homeostasis and hepatic injuryR00DK120876 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TOMAR, DHANENDRA · 2022 to 2024
$986k
Impact of mitochondrial structure on cellular homeostasis and hepatic injuryK99DK120876 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI TOMAR, DHANENDRA · 2020 to 2021
$181k
The Role of MICU3 in Alzheimer's Disease PathogenesisF30AG082407 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI Henry Cohen · 2023 to 2026
$178k
Molecular modulation of the mitochondrial Na+/Ca2+ exchanger as a novel therapeutic target for heart failure.F32HL151146 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GARBINCIUS, JOANNE FRANCES · 2020 to 2021
$134k
NHLBI NIH HHS F32 HL151146NHLBI NIH HHS P01 HL134608NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL142271NHLBI NIH HHS T32 HL091804NIA NIH HHS F30 AG082407NIDDK NIH HHS K99 DK120876NIDDK NIH HHS R00 DK120876NINDS NIH HHS R01 NS121379NINDS NIH HHS RF1 NS121379
6 · The paper itself

Abstract

The balance between mitochondrial calcium (

Indexed as

calciummitochondriaNCLXsodiumTMEM65

Identifiers

PMID37873405
PMCPMC10592617
OpenAlexW4387500340

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.