Evidence map›Paper›PMID 37873381›Full record

ArticlebioRxiv : the preprint server for biology2023

Disruption of myelin structure and oligodendrocyte maturation in a pigtail macaque model of congenital Zika infection.

Jennifer Tisoncik-Go, Caleb Stokes, Leanne S Whitmore, Daniel J Newhouse, Kathleen Voss, Andrew Gustin, Cheng-Jung Sung, Elise Smith, Jennifer Stencel-Baerenwald, Edward Parker and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Jennifer Tisoncik-GoCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Caleb StokesCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Leanne S WhitmoreCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Daniel J NewhouseCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Kathleen VossCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Andrew GustinCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Cheng-Jung SungCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Elise SmithCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Jennifer Stencel-BaerenwaldCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
Edward ParkerDepartment of Ophthalmology, NEI Core for Vision Research, University of Washington, Seattle, Washington, USA.
Jessica M SnyderDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Dennis W ShawDepartment of Radiology, University of Washington, Seattle Washington, USA.
Lakshmi RajagopalDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Raj P KapurDepartment of Pathology, University of Washington, Seattle, Washington, USA.
Kristina Adams WaldorfDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Michael GaleCenter for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA.
University of Washington · USInfectious Disease Research Institute · USSeattle Children's Hospital · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
JAK-STAT Control of Zika Virus-Induced Fetal InjuryR01AI143265 · NIAID · UNIVERSITY OF WASHINGTON · PI ADAMS WALDORF, KRISTINA M., GALE, MICHAEL · 2019 to 2023
$4.6M
Innate Immune Regulation of Zika Virus InfectionR01AI145296 · NIAID · UNIVERSITY OF WASHINGTON · PI COYNE, CAROLYN B, DIAMOND, MICHAEL S · 2019 to 2023
$4.1M
Innate Immunity of Zika Virus Infection In Human Neural ProgenitorsK08AI150996 · NIAID · UNIVERSITY OF WASHINGTON · PI STOKES, CALEB · 2020 to 2024
$975k
NEI NIH HHS P30 EY001730NIAID NIH HHS HHSN272201800008CNIAID NIH HHS HHSN272201800008INIAID NIH HHS K08 AI150996NIAID NIH HHS R01 AI143265NIAID NIH HHS R01 AI145296NIH HHS P51 OD010425
6 · The paper itself

Abstract

Zika virus (ZikV) infection during pregnancy can cause congenital Zika syndrome (CZS) and neurodevelopmental delay in non-microcephalic infants, of which the pathogenesis remains poorly understood. We utilized an established pigtail macaque maternal-to-fetal ZikV infection/exposure model to study fetal brain pathophysiology of CZS manifesting from ZikV exposure

Identifiers

PMID37873381
PMCPMC10592731
OpenAlexW4387655068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.