Evidence map›Paper›PMID 37873374›Full record

ArticlebioRxiv : the preprint server for biology2024

Dopamine lesions alter the striatal encoding of single-limb gait.

Long Yang, Deepak Singla, Alexander K Wu, Katy A Cross, Sotiris C Masmanidis

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Long YangDepartment of Neurobiology, University of California Los Angeles, Los Angeles, California 90095, USA.
Deepak SinglaDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, USA.
Alexander K WuDepartment of Neurobiology, University of California Los Angeles, Los Angeles, California 90095, USA.
Katy A CrossDepartment of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA.
Sotiris C MasmanidisDepartment of Neurobiology, University of California Los Angeles, Los Angeles, California 90095, USA.ORCID 0000-0002-8699-3335
University of California, Los Angeles · USCalifornia NanoSystems Institute · US

Funding

CRCNS: Multiple Clocks for the Encoding of Time in Corticostriatal CircuitsR01NS125877 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUONOMANO, DEAN V, MASMANIDIS, SOTIRIS · 2021 to 2025
$1.9M
NINDS NIH HHS R01 NS125877
6 · The paper itself

Abstract

The striatum serves an important role in motor control, and neurons in this area encode the body's initiation, cessation, and speed of locomotion. However, it remains unclear whether the same neurons also encode the step-by-step rhythmic motor patterns of individual limbs that characterize gait. By combining high-speed video tracking, electrophysiology, and optogenetic tagging, we found that a sizable population of both D1 and D2 receptor expressing medium spiny projection neurons (MSNs) were phase-locked to the gait cycle of individual limbs in mice. Healthy animals showed balanced limb phase-locking between D1 and D2 MSNs, while dopamine depletion led to stronger phase-locking in D2 MSNs. These findings indicate that striatal neurons represent gait on a single-limb and step basis, and suggest that elevated limb phase-locking of D2 MSNs may underlie some of the gait impairments associated with dopamine loss.

Identifiers

PMID37873374
PMCPMC10592622
OpenAlexW4387500427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.