Evidence map›Paper›PMID 37873369›Full record

ArticlebioRxiv : the preprint server for biology2024

Heterozygous expression of a

Amy N Shore, Keyong Li, Mona Safari, Alshaima'a M Qunies, Brittany D Spitznagel, C David Weaver, Kyle A Emmitte, Wayne N Frankel, Matthew C Weston

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Amy N ShoreFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, VA, USA.
Keyong LiFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, VA, USA.
Mona SafariFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, VA, USA.
Alshaima'a M QuniesDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Brittany D SpitznagelDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
C David WeaverDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Kyle A EmmitteDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Wayne N FrankelInstitute for Genomic Medicine, Columbia University, New York, NY, USA.ORCID 0000-0003-2241-5314
Matthew C WestonFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, VA, USA.ORCID 0000-0001-5558-7070
Carilion Clinic · USUniversity of North Texas · USUniversity of Vermont · USVanderbilt University · USColumbia University · US

Funding

GENETIC DETERMINANTS OF EPILEPSY IN MURINE SYSTEMSR01NS031348 · NINDS · JACKSON LABORATORY · PI SANDS, TRISTAN T · 1993 to 2025
$11.5M
The Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI FRANKEL, WAYNE N. · 2015 to 2019
$10.2M
Genetic Determinants of Epilepsy in Murine SystemsR37NS031348 · NINDS · JACKSON LABORATORY · PI FRANKEL, WAYNE N. · 2014 to 2020
$5.8M
Synaptic changes and hypersynchronous network activity in mTORopathiesR01NS110945 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WESTON, MATTHEW C · 2019 to 2023
$1.7M
Cell Type-Specific Roles of the Na-Activated K Current in KCNT1-Related EpilepsyR01NS130042 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Matthew C Weston · 2023 to 2026
$1.6M
Slack Potassium Channel Inhibitors for the Treatment of Childhood EpilepsiesR33NS109521 · NINDS · VANDERBILT UNIVERSITY · PI EMMITTE, KYLE A, WEAVER, C DAVID · 2020 to 2021
$787k
Regulation of synapse and network dynamics at MTORR00NS087095 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI WESTON, MATTHEW C · 2016 to 2018
$744k
REGULATION OF SYNAPSE AND NETWORK DYNAMICS BY MTORK99NS087095 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI WESTON, MATTHEW C · 2014 to 2015
$179k
NIH HHS U54 OD020351NINDS NIH HHS K99 NS087095NINDS NIH HHS R00 NS087095NINDS NIH HHS R01 NS031348NINDS NIH HHS R01 NS110945NINDS NIH HHS R01 NS130042NINDS NIH HHS R33 NS109521NINDS NIH HHS R37 NS031348
6 · The paper itself

Abstract

More than twenty recurrent missense gain-of-function (GOF) mutations have been identified in the sodium-activated potassium (K

Indexed as

ADNFLEDEEelectrophysiologyepilepsyGABAergicglutamatergicGOF variantKCNT1 channelKNa currentpotassium channelPVSlackSSTVIP

Identifiers

PMID37873369
PMCPMC10592778
OpenAlexW4387573229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.