Evidence map›Paper›PMID 37873357›Full record

ArticlebioRxiv : the preprint server for biology2024

Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells.

Yingying Chen, Jeong Han Lee, Jin Li, Seojin Park, Maria C Perez Flores, Braulio Peguero, Jennifer Kersigo, Mincheol Kang, Jinsil Choi, Lauren Levine and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yingying ChenUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Jeong Han LeeUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Jin LiDepartment of Otolaryngology, University of Washington Seattle, WA, USA.
Seojin ParkUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Maria C Perez FloresUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Braulio PegueroOtolaryngology-Head, Neck Surgery, St. Louis University, St. Louis, Missouri 63108.
Jennifer KersigoUniversity of Iowa, Department of Biology Iowa City, IA.
Mincheol KangUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Jinsil ChoiUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Lauren LevineUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Michael Anne GrattonUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.
Bernd FritzschUniversity of Iowa, Department of Biology Iowa City, IA.
Ebenezer N YamoahUniversity of Nevada, Reno, School of Medicine, Department of Physiology and Cell Biology, Reno NV 89557.ORCID 0000-0002-9797-085X
University of Nevada, Reno · USUniversity of Iowa · USSaint Louis University · USUniversity of Washington · US

Funding

Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2016 to 2025
$15.5M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
Regulation of hair cell functionsR01DC015252 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2017 to 2021
$2.1M
NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC015252NIDCD NIH HHS R01 DC016099
6 · The paper itself

Abstract

Hearing loss is the most common form of sensory deficit. It occurs predominantly due to hair cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss challenging to replace. Here, we show the pharmacogenetic downregulation of

Identifiers

PMID37873357
PMCPMC10592694
OpenAlexW4387491277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.