Evidence map›Paper›PMID 37873346›Full record

ArticlebioRxiv : the preprint server for biology2023

The impact of short-term forearm immobilization and acipimox administration on muscle amino acid metabolism and insulin sensitivity in healthy, young volunteers.

Marlou L Dirks, Tom S O Jameson, Rob C Andrews, Mandy V Dunlop, Doaa R Abdelrahman, Andrew J Murton, Benjamin T Wall, Francis B Stephens

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Marlou L DirksDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.
Tom S O JamesonDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.
Rob C AndrewsInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Mandy V DunlopDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.
Doaa R AbdelrahmanDepartment of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Andrew J MurtonDepartment of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Benjamin T WallDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.
Francis B StephensDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.
University of Exeter · GBThe University of Texas Medical Branch at Galveston · US

Funding

UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
NIA NIH HHS P30 AG024832Wellcome Trust
6 · The paper itself

Abstract

The mechanisms underpinning short-term muscle disuse atrophy remain to be elucidated, but perturbations in lipid metabolism may be involved. Specifically, positive muscle non-esterified fatty acid (NEFA) balance has been implicated in the development of disuse-induced insulin and anabolic resistance. Our aim was to determine the impact of acipimox administration (i.e. pharmacologically lowering circulating NEFA availability) on muscle amino acid metabolism and insulin sensitivity during short-term disuse. Eighteen healthy individuals (age 22±1 years, BMI 24.0±0.6 kg·m

Indexed as

amino acid kineticsanabolic resistancedisuse atrophyinsulin sensitivitylipidskeletal muscle

Identifiers

PMID37873346
PMCPMC10592751
OpenAlexW4387603978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.