Evidence map›Paper›PMID 37873341›Full record

ArticlebioRxiv : the preprint server for biology2023

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation.

Muhammad Khatib, Eric Tianjiao Zhao, Shiyuan Wei, Alex Abramson, Estelle Spear Bishop, Chih-Hsin Chen, Anne-Laure Thomas, Chengyi Xu, Jaeho Park, Yeongjun Lee and 22 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Muhammad KhatibDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Eric Tianjiao ZhaoDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Shiyuan WeiDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Alex AbramsonDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Estelle Spear BishopDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Chih-Hsin ChenDepartment of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
Anne-Laure ThomasDepartment of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
Chengyi XuDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Jaeho ParkDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Yeongjun LeeDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Ryan HamnettDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Weilai YuDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Samuel E RootDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Lei YuanDepartment of Biology, Stanford University, Stanford, CA, USA.
Dorine ChakhtouraDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Kyun Kyu KimDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Donglai ZhongDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Yuya NishioDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Chuanzhen ZhaoDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Can WuDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Yuanwen JiangDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Anqi ZhangDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Jinxing LiDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Weichen WangDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Fereshteh Salimi-JaziDepartment of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
Talha A RafeeqiDepartment of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
Nofar Mintz HemedDepartment of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States.
Jeffrey B-H TokDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Xiaoke ChenDepartment of Biology, Stanford University, Stanford, CA, USA.
Julia A KaltschmidtDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
James C Y DunnDepartment of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
Zhenan BaoDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

Funding

Multiparametric deep tissue microscope for in vivo and in vitro imagingS10OD032300 · OD · STANFORD UNIVERSITY · PI O'BRIEN, LUCY ERIN · 2022 to 2022
$600k
Skin-like wearable biosensors for multimodal mental health biomarker monitoringF32EB034156 · NIBIB · STANFORD UNIVERSITY · PI ZHAO, CHUANZHEN · 2023 to 2024
$151k
Biocompatible strain sensors for continuous monitoring of tumor progression during immunotherapy treatmentsF32EB029787 · NIBIB · STANFORD UNIVERSITY · PI ABRAMSON, ALEX · 2020 to 2021
$131k
NIBIB NIH HHS F32 EB029787NIBIB NIH HHS F32 EB034156NIH HHS S10 OD032300
6 · The paper itself

Abstract

Bioelectronic fibers hold promise for both research and clinical applications due to their compactness, ease of implantation, and ability to incorporate various functionalities such as sensing and stimulation. However, existing devices suffer from bulkiness, rigidity, limited functionality, and low density of active components. These limitations stem from the difficulty to incorporate many components on one-dimensional (1D) fiber devices due to the incompatibility of conventional microfabrication methods (e.g., photolithography) with curved, thin and long fiber structures. Herein, we introduce a fabrication approach, ‶spiral transformation″, to convert two-dimensional (2D) films containing microfabricated devices into 1D soft fibers. This approach allows for the creation of high density multimodal soft bioelectronic fibers, termed Spiral NeuroString (S-NeuroString), while enabling precise control over the longitudinal, angular, and radial positioning and distribution of the functional components. We show the utility of S-NeuroString for motility mapping, serotonin sensing, and tissue stimulation within the dynamic and soft gastrointestinal (GI) system, as well as for single-unit recordings in the brain. The described bioelectronic fibers hold great promises for next-generation multifunctional implantable electronics.

Identifiers

PMID37873341
PMCPMC10592902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.