Evidence map›Paper›PMID 37873316›Full record

ArticlebioRxiv : the preprint server for biology2023

Dysfunctional T Follicular Helper Cells Cause Intestinal and Hepatic Inflammation in NASH.

Haiguang Wang, Fanta Barrow, Gavin Fredrickson, Kira Florczak, Huy Nguyen, Preethy Parthiban, Adam Herman, Oyedele Adeyi, Christopher Staley, Sayeed Ikramuddin and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Haiguang WangDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Fanta BarrowDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Gavin FredricksonDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Kira FlorczakDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Huy NguyenDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Preethy ParthibanDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Adam HermanDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Oyedele AdeyiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Christopher StaleyDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Sayeed IkramuddinDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Hai-Bin RuanDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Stephen C JamesonCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Xavier S ReveloDepartment of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

Minnesota Obesity Prevention Training (MnOPT)T32DK083250 · NIDDK · UNIVERSITY OF MINNESOTA · PI KOTZ, CATHERINE M, LASKA, MELISSA N. · 2010 to 2024
$5.1M
Immune Mechanisms Regulating Cardiac RemodelingR01HL155993 · NHLBI · UNIVERSITY OF MINNESOTA · PI REVELO, XAVIER, VAN BERLO, JOHANNES (JOP) · 2021 to 2024
$2.9M
Mechanisms of B Cell Pathogenicity in Non-Alcoholic Fatty Liver DiseaseR01DK122056 · NIDDK · UNIVERSITY OF MINNESOTA · PI REVELO, XAVIER · 2019 to 2023
$1.7M
NHLBI NIH HHS R01 HL155993NIDDK NIH HHS R01 DK122056NIDDK NIH HHS T32 DK083250
6 · The paper itself

Abstract

Nonalcoholic steatohepatitis (NASH), characterized by hepatic inflammation and cellular damage, is the most severe form of nonalcoholic fatty liver disease and the fastest-growing indication for a liver transplant. The intestinal immune system is a central modulator of local and systemic inflammation. In particular, Peyer's patches (PPs) contain T follicular helper (Tfh) cells that support germinal center (GC) responses required for the generation of high-affinity intestinal IgA and the maintenance of intestinal homeostasis. However, our understanding of the mechanisms regulating mucosal immunity during the pathogenesis of NASH is incomplete. Here, using a preclinical mouse model that resembles the key features of human disease, we discovered an essential role for Tfh cells in the pathogenesis of NASH. We have found that mice fed a high-fat high-carbohydrate (HFHC) diet have an inflamed intestinal microenvironment, characterized by enlarged PPs with an expansion of Tfh cells. Surprisingly, the Tfh cells in the PPs of NASH mice showed evidence of dysfunction, along with defective GC responses and reduced IgA

Identifiers

PMID37873316
PMCPMC10592647
OpenAlexW4379984020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.