Evidence map›Paper›PMID 37873304›Full record

ArticlebioRxiv : the preprint server for biology2023

Qing Chen, Safia Malki, Xiaojiang Xu, Brian Bennett, Brad L Lackford, Oleksandr Kirsanov, Christopher B Geyer, Guang Hu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Qing ChenEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Safia MalkiEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Xiaojiang XuIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Brian BennettIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Brad L LackfordEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Oleksandr KirsanovDepartment of Anatomy & Cell Biology, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
Christopher B GeyerDepartment of Anatomy & Cell Biology, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
Guang HuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
National Institute of Environmental Health Sciences · USEast Carolina University · USTulane University · US

Funding

Challenging the role of retinoic acid in meiotic initiationR21HD105963 · NICHD · EAST CAROLINA UNIVERSITY · PI GEYER, CHRISTOPHER BENNETT · 2022 to 2023
$424k
NICHD NIH HHS R21 HD105963
6 · The paper itself

Abstract

The foundation of spermatogenesis and lifelong fertility is provided by spermatogonial stem cells (SSCs). SSCs divide asymmetrically to either replenish their numbers (self-renewal) or produce undifferentiated progenitors that proliferate before committing to differentiation. However, regulatory mechanisms governing SSC maintenance are poorly understood. Here, we show that the CCR4-NOT mRNA deadenylase complex subunit CNOT3 plays a critical role in maintaining spermatogonial populations in mice.

Indexed as

glutathione redox pathwaymaintenancescRNA-seqspermatogenesisSpermatogonial stem cells

Identifiers

PMID37873304
PMCPMC10592795
OpenAlexW4387639220

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.