Evidence map›Paper›PMID 37873286›Full record

ArticlebioRxiv : the preprint server for biology2023

A developmentally defined population of neurons in the lateral septum controls responses to aversive stimuli.

Miguel Turrero García, Diana N Tran, Ralph E Peterson, Sarah K Stegmann, Sarah M Hanson, Christopher M Reid, Yajun Xie, Steve Vu, Corey C Harwell

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Miguel Turrero GarcíaDepartment of Neurology, University of California, San Francisco; San Francisco, CA.
Diana N TranDepartment of Neurobiology, Harvard Medical School; Boston, MA.
Ralph E PetersonDepartment of Neurobiology, Harvard Medical School; Boston, MA.
Sarah K StegmannDepartment of Neurobiology, Harvard Medical School; Boston, MA.
Sarah M HansonDepartment of Neurology, University of California, San Francisco; San Francisco, CA.
Christopher M ReidDepartment of Neurology, University of California, San Francisco; San Francisco, CA.
Yajun XieDepartment of Neurology, University of California, San Francisco; San Francisco, CA.
Steve VuDepartment of Neurobiology, Harvard Medical School; Boston, MA.
Corey C HarwellDepartment of Neurology, University of California, San Francisco; San Francisco, CA.
Harvard University · USUniversity of California, San Francisco · USBoston University · US

Funding

Epigenetic Regulation of Cortical Neuronal Lineage ProgressionR01NS102228 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARWELL, COREY C · 2017 to 2021
$1.9M
Temporal Specification of Basal Forebrain CircuitryR01MH119156 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARWELL, COREY C · 2020 to 2023
$1.9M
NIMH NIH HHS R01 MH119156NINDS NIH HHS R01 NS102228
6 · The paper itself

Abstract

When interacting with their environment, animals must balance exploratory and defensive behavior to evaluate and respond to potential threats. The lateral septum (LS) is a structure in the ventral forebrain that calibrates the magnitude of behavioral responses to stress-related external stimuli, including the regulation of threat avoidance. The complex connectivity between the LS and other parts of the brain, together with its largely unexplored neuronal diversity, makes it difficult to understand how defined LS circuits control specific behaviors. Here, we describe a mouse model in which a population of neurons with a common developmental origin (

Identifiers

PMID37873286
PMCPMC10592641
OpenAlexW4387019765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.