Evidence map›Paper›PMID 37873280›Full record

ArticlebioRxiv : the preprint server for biology2023

IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering.

Santosh Karnewar, Vaishnavi Karnewar, Rebecca Deaton, Laura S Shankman, Ernest D Benavente, Corey M Williams, Xenia Bradley, Gabriel F Alencar, Gamze B Bulut, Sara Kirmani and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Santosh KarnewarRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Vaishnavi KarnewarRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Rebecca DeatonRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Laura S ShankmanRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Ernest D BenaventeLaboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Corey M WilliamsRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Xenia BradleyRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Gabriel F AlencarRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Gamze B BulutRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Sara KirmaniRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Richard A BaylisRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Eli R ZunderRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
Hester M den RuijterLaboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Gerard PasterkampLaboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Gary K OwensRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA.
University of Virginia · USUtrecht University · NL

Funding

Endothelial Cell to Mesenchymal Cell Transitions Play a Critical Biological Sex- and Aging-Dependent Role in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous CapR01HL156849 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2022 to 2025
$3.2M
IL1beta signaling in SMCpromotes beneficial changes in late stage atherosclerotic lesion pathogenesisR01HL141425 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2019 to 2022
$3.1M
Role of Metabolic Reprogramming in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous CapR01HL155165 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2021 to 2024
$2.9M
NHLBI NIH HHS R01 HL141425NHLBI NIH HHS R01 HL155165NHLBI NIH HHS R01 HL156849
6 · The paper itself

Abstract

Background: Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the leading cause of death in the world. The most common and effective means to reduce these major adverse cardiovascular events (MACE), including myocardial infarction (MI) and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, little is known regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering. Methods: Smooth muscle cell (SMC)-lineage tracing Results: Lipid-lowering by switching Conclusions: Taken together, IL-1β appears to be required for chow diet-induced reductions in plaque burden and increases in multiple indices of plaque stability.

Indexed as

anti-inflammatory therapyAtherosclerosischow diet-induced lipid loweringIL-1βsmooth muscle cell

Identifiers

PMID37873280
PMCPMC10592822
OpenAlexW4387638621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.