Evidence map›Paper›PMID 37873277›Full record

ArticlebioRxiv : the preprint server for biology2023

Double-strand break repair-associated intragenic deletions and tandem duplications suggest the architecture of the repair replication fork.

Simona Dalin, Sophie Webster, Neal Sugawara, Shu Zhang, Qiuqin Wu, Tracy Cui, Victoria Liang, Rameen Beroukhim, James E Haber

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Simona DalinCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sophie WebsterCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Neal SugawaraRosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110.
Shu ZhangCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Qiuqin WuRosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110.
Tracy CuiCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Victoria LiangRosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110.
Rameen BeroukhimCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
James E HaberRosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110.
Broad Institute · USBrandeis University · US

Funding

MYB family alterations in pediatric gliomasR01CA215489 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, LIGON, KEITH LLOYD · 2017 to 2021
$2.8M
Characterizing TP53 and PPM1D mutations as resistance drivers to radiation therapy in Diffuse Intrinsic Pontine GliomasR01CA219943 · NCI · BROAD INSTITUTE, INC. · PI BEROUKHIM, RAMEEN, LIGON, KEITH LLOYD · 2017 to 2021
$2.5M
Differential resistance mechanisms to monofunctional vs bifunctional alkylating agents in gliomaF32CA261024 · NCI · BROAD INSTITUTE, INC. · PI DALIN, SIMONA · 2021 to 2023
$208k
NCI NIH HHS F32 CA261024NCI NIH HHS R01 CA215489NCI NIH HHS R01 CA219943
6 · The paper itself

Abstract

Double-strand break (DSB) repair is associated with a 1000-fold increase in mutations compared to normal replication of the same sequences. In budding yeast, repair of an HO endonuclease-induced DSB at the

Identifiers

PMID37873277
PMCPMC10592705
OpenAlexW4387572817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.