Evidence map›Paper›PMID 37873260›Full record

ArticlebioRxiv : the preprint server for biology2023

Quantitative Profiling Method for Oxylipins in Neurodegenerative Diseases by Liquid Chromatography Coupled with Tandem Mass Spectrometry.

Elham Pourmand, Fan Zhang, Morteza Sarparast, Jamie K Alan, Kin Sing Stephen Lee

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elham PourmandDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Fan ZhangDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Morteza SarparastDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Jamie K AlanDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Kin Sing Stephen LeeDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Michigan State University · US

Funding

Ferroptosis and Polyunsaturated Fatty Acid MetabolismR35GM146983 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Kin Sing Stephen Lee · 2022 to 2026
$2.0M
Oxylipins, aging and Alzheimer’s diseaseR03AG075465 · NIA · MICHIGAN STATE UNIVERSITY · PI LEE, KIN SING STEPHEN · 2022 to 2023
$305k
NIA NIH HHS R03 AG075465NIGMS NIH HHS R35 GM146983
6 · The paper itself

Abstract

Aging is one of the major risk factors for many chronic diseases, including diabetes, neuropathy, hypertension, cancer, and neurodegenerative diseases. However, the mechanism behind aging and how aging affects a variety of disease progression remains unknown. Recent research demonstrated the cytochrome P450 (CYP)-epoxide hydrolase (EH) metabolites of polyunsaturated fatty acids (PUFAs) play a critical role in the abovementioned age-associated diseases. Therefore, aging could affect the abovementioned chronic diseases by modulating CYP-EH PUFA metabolism. Unfortunately, investigating how aging affects CYP-EH metabolism in human and mammalian models poses significant challenges. In this regard, we will use

Identifiers

PMID37873260
PMCPMC10592938
OpenAlexW4387310675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.