Evidence map›Paper›PMID 37873252›Full record

ArticlebioRxiv : the preprint server for biology2023

Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation.

Chenzhou Wu, Xiaomin Cai, Ying Wang, Carlos D Rodriguez, Lydia Herrmann, Giorgia Zoaldi, Chun-Yuh Huang, Xiaoqiong Wang, Viraj R Sanghvi, Rongze O Lu and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chenzhou WuDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Xiaomin CaiDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ying WangDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Carlos D RodriguezDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lydia HerrmannDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Giorgia ZoaldiDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Chun-Yuh HuangDepartment of Biomedical Engineering, University of Miami, 1251 Memorial Drive, Coral Gables, FL 33146, USA.
Xiaoqiong WangSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Viraj R SanghviSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Rongze O LuBrain Tumor Center, Department of Neurological Surgery, Helen Diller Cancer Center, UCSF, San Francisco, CA, USA.
Zhipeng MengDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
University of Miami · USNeurological Surgery · US

Funding

Understand Glycation: The Sweet Side of Protein RegulationR35GM147497 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI viraj sanghvi · 2022 to 2026
$2.0M
Roles of mechanotransduction in organ regeneration and fibrosisR35GM142504 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MENG, ZHIPENG · 2021 to 2025
$2.0M
Regulation of Macrophage- and Microglia-mediated STING Signaling in GlioblastomaR01NS126501 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rongze Olivia Lu · 2022 to 2026
$1.9M
Comprehensive Research Experiences to Advance Training and Education (CREATE) for Future Cancer ResearchersR25CA261632 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kerry L Burnstein, Claude-Henry Volmar · 2021 to 2026
$1.7M
NCI NIH HHS R25 CA261632NIGMS NIH HHS R35 GM142504NIGMS NIH HHS R35 GM147497NINDS NIH HHS R01 NS126501
6 · The paper itself

Abstract

The Hippo signaling is instrumental in regulating organ size, regeneration, and carcinogenesis. The cytoskeleton emerges as a primary Hippo signaling modulator. Its structural alterations in response to environmental and intrinsic stimuli control Hippo kinase cascade activity. However, the precise mechanisms underlying the cytoskeleton regulation of Hippo signaling are not fully understood. RAP2 GTPase is known to mediate the mechanoresponses of Hippo signaling

Indexed as

cytoskeletonenergy stressHippo signalingMAP4KmechanotransductionRAP2 GTPase

Identifiers

PMID37873252
PMCPMC10592777
OpenAlexW4387538494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.