Evidence map›Paper›PMID 37873218›Full record

ArticlebioRxiv : the preprint server for biology2024

Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli.

Sebastian Jojoa-Cruz, Adrienne E Dubin, Wen-Hsin Lee, Andrew Ward

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sebastian Jojoa-CruzDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, California 92037, USA.ORCID 0000-0002-4392-3898
Adrienne E DubinDepartment of Neuroscience, Scripps Research, La Jolla, California 92037, USA.
Wen-Hsin LeeDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, California 92037, USA.ORCID 0000-0001-9445-6671
Andrew WardDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, California 92037, USA.ORCID 0000-0001-7153-3769
Scripps Institution of Oceanography · US

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Mechanisms of force sensing in the nervous systemR35NS105067 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI PATAPOUTIAN, ARDEM · 2018 to 2025
$6.1M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Molecular understanding of membrane sensorsR01HL143297 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI PATAPOUTIAN, ARDEM, WARD, ANDREW BARRETT · 2019 to 2022
$3.2M
NHLBI NIH HHS R01 HL143297NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R01 GM129325NINDS NIH HHS R35 NS105067
6 · The paper itself

Abstract

The dimeric two-pore OSCA/TMEM63 family has recently been identified as mechanically activated ion channels. Previously, based on the unique features of the structure of OSCA1.2, we postulated the potential involvement of several structural elements in sensing membrane tension

Identifiers

PMID37873218
PMCPMC10592937
OpenAlexW4387338582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.