Evidence map›Paper›PMID 37873217›Full record

ArticlebioRxiv : the preprint server for biology2024

Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome.

Amin Md Shakhawat, Jacqueline G Foltz, Adam B Nance, Jaydev Bhateja, Jennifer L Raymond

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amin Md ShakhawatDepartment of Neurobiology, Stanford University, Stanford, California 94305-5125.ORCID 0000-0002-3776-3699
Jacqueline G FoltzDepartment of Neurobiology, Stanford University, Stanford, California 94305-5125.
Adam B NanceDepartment of Neurobiology, Stanford University, Stanford, California 94305-5125.
Jaydev BhatejaDepartment of Neurobiology, Stanford University, Stanford, California 94305-5125.
Jennifer L RaymondDepartment of Neurobiology, Stanford University, Stanford, California 94305-5125.ORCID 0000-0002-8145-747X
Stanford University · US

Funding

VESTIBULAR AND VISUAL CONTROL OF EYE MOVEMENTR01DC004154 · NIDCD · STANFORD UNIVERSITY · PI GOLDMAN, MARK S, RAYMOND, JENNIFER L · 1999 to 2025
$9.6M
Instructive Signals for Motor LearningR01NS072406 · NINDS · STANFORD UNIVERSITY · PI Jennifer L Raymond · 2010 to 2026
$7.6M
Activity-Dependent Mechanisms of Memory ConsolidationR01EY031972 · NEI · STANFORD UNIVERSITY · PI GOLDMAN, MARK S, RAYMOND, JENNIFER L · 2021 to 2025
$3.0M
NEI NIH HHS R01 EY031972NIDCD NIH HHS R01 DC004154NINDS NIH HHS R01 NS072406
6 · The paper itself

Abstract

The enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments can result from saturation of the plasticity mechanism (Nguyen-Vu et al., 2017), or, more generally, from a history-dependent change in the threshold for plasticity. This hypothesis was based on experimental results from mice lacking two class I major histocompatibility molecules, MHCI H2-K

Identifiers

PMID37873217
PMCPMC10592955
OpenAlexW4387406465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.