Evidence map›Paper›PMID 37873210›Full record

ArticlebioRxiv : the preprint server for biology2024

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS.

Huanhuan Joyce Chen, Eric E Gardner, Yajas Shah, Kui Zhang, Abhimanyu Thakur, Chen Zhang, Olivier Elemento, Harold Varmus

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Huanhuan Joyce ChenMeyer Cancer Center, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-1446-7184
Eric E GardnerMeyer Cancer Center, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-1552-2675
Yajas ShahCaryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-9692-4878
Kui ZhangThe Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL.ORCID 0000-0001-9618-610X
Abhimanyu ThakurThe Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL.ORCID 0000-0002-0846-0998
Chen ZhangDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.
Olivier ElementoCaryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-8061-9617
Harold VarmusMeyer Cancer Center, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-6444-1943
Cornell University · USUniversity of Chicago · US

Funding

Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cellsU01CA224326 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI VARMUS, HAROLD E. · 2018 to 2022
$2.4M
Investigation of sub-lineages in pulmonary neuroendocrine cells and identification of the cells of origin of small cell lung cancerR00CA226353 · NCI · UNIVERSITY OF CHICAGO · PI CHEN, JOYCE HUANHUAN · 2020 to 2022
$747k
Unraveling Metastasis Drivers in Small Cell Lung Cancer via Human Pluripotent Stem Cell-Based ApproachR21CA299377 · NCI · UNIVERSITY OF CHICAGO · PI Joyce Huanhuan Chen · 2025 to 2026
$422k
Investigation of sub-lineages in pulmonary neuroendocrine cells and identification of the cells of origin of small cell lung cancerK99CA226353 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, JOYCE HUANHUAN · 2019 to 2019
$84k
NCI NIH HHS K99 CA226353NCI NIH HHS R00 CA226353NCI NIH HHS R21 CA299377NCI NIH HHS U01 CA224326
6 · The paper itself

Abstract

We recently described our initial efforts to develop a model for small cell lung cancer (SCLC) derived from human embryonic stem cells (hESCs) that were differentiated to form pulmonary neuroendocrine cells (PNECs), a putative cell of origin for neuroendocrine-positive SCLC. Although reduced expression of the tumor suppressor genes

Identifiers

PMID37873210
PMCPMC10592623
OpenAlexW4387501334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.