Evidence map›Paper›PMID 37873203›Full record

ArticlebioRxiv : the preprint server for biology2024

Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis.

Ping Kang, Peiduo Liu, Jinoh Kim, Ankur Kumar, Marie Bolton, Wren Murzyna, Zenessa J Anderson, Lexi N Frank, Nicholas Kavlock, Elizabeth Hoffman and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Ping KangDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Peiduo LiuDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Jinoh KimDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Ankur KumarDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Marie BoltonDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Wren MurzynaDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Zenessa J AndersonDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Lexi N FrankDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Nicholas KavlockDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Elizabeth HoffmanDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Chad C MartinDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Marlene K Dorneich-HayesDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Ting MiaoDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
MaryJane ShimellDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Weihang ChenDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Yanhui HuDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Jo Anne Powell-CoffmanDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Michael B O'ConnorDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Norbert PerrimonDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Hua BaiDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.
Iowa State University · USHarvard University · USUniversity of Minnesota · USHoward Hughes Medical Institute · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Functional genomics resources for the Drosophila - TR&D3P41GM132087 · NIGMS · HARVARD MEDICAL SCHOOL · PI MOHR, STEPHANIE E · 2019 to 2023
$6.8M
Interorgan communication in aging in DrosophilaU01AG086143 · NIA · HARVARD MEDICAL SCHOOL · PI Hongjie Li, NORBERT PERRIMON · 2024 to 2026
$2.0M
Autonomous and Non-Autonomous Regulation of Cardiac AgingR01AG058741 · NIA · IOWA STATE UNIVERSITY · PI BAI, HUA · 2019 to 2023
$1.5M
Role of peroxisome-mitochondrion communication in tissue agingR01AG075156 · NIA · IOWA STATE UNIVERSITY · PI Hua Bai · 2023 to 2026
$1.2M
NIA NIH HHS R01 AG058741NIA NIH HHS R01 AG075156NIA NIH HHS U01 AG086143NIGMS NIH HHS P41 GM132087NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itself

Abstract

The prothoracicotropic hormone (PTTH) is a well-known neuropeptide that regulates insect metamorphosis (the juvenile-to-adult transition) by inducing the biosynthesis of steroid hormones. However, the role of PTTH in adult physiology and longevity is largely unexplored. Here, we show that

Indexed as

Developmental theory of agingliver inflammagingNF-kB/RelishoenocytePTTH

Identifiers

PMID37873203
PMCPMC10592873
OpenAlexW4387246760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.