Evidence map›Paper›PMID 37873182›Full record

ArticlebioRxiv : the preprint server for biology2023

Pseudo-linear Summation explains Neural Geometry of Multi-finger Movements in Human Premotor Cortex.

Nishal P Shah, Donald Avansino, Foram Kamdar, Claire Nicolas, Anastasia Kapitonava, Carlos Vargas-Irwin, Leigh Hochberg, Chethan Pandarinath, Krishna Shenoy, Francis R Willett and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Nishal P ShahDepartment of Neurosurgery, Stanford University.
Donald AvansinoHoward Hughes Medical Institute at Stanford University, Stanford, CA, USA.
Foram KamdarDepartment of Neurosurgery, Stanford University.
Claire NicolasCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Anastasia KapitonavaCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Carlos Vargas-IrwinVA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Providence VA Medical Center, Providence, RI, USA.
Leigh HochbergVA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Providence VA Medical Center, Providence, RI, USA.
Chethan PandarinathWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Krishna ShenoyHoward Hughes Medical Institute at Stanford University, Stanford, CA, USA.
Francis R WillettHoward Hughes Medical Institute at Stanford University, Stanford, CA, USA.
Jaimie HendersonDepartment of Neurosurgery, Stanford University.
Howard Hughes Medical Institute · USAllen Institute for Brain Science · USHarvard University · USStanford University · USGeorgia Institute of Technology · USNeurosciences Institute · US

Funding

Engaging new cognitive and motor signals to improve communication prosthesesR01DC014034 · NIDCD · STANFORD UNIVERSITY · PI JAIMIE M HENDERSON · 2015 to 2026
$8.2M
Understanding the Neural Basis of Volitional State through Continuous Recordings in HumansU01NS098968 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2016 to 2018
$4.7M
Intuitive, complete neural control of tablet computers for communicationU01DC017844 · NIDCD · BROWN UNIVERSITY · PI HOCHBERG, LEIGH R · 2019 to 2025
$4.3M
High-Bandwidth Wireless Interfaces for Continuous Human Intracortical RecordingUH2NS095548 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HOCHBERG, LEIGH R, NURMIKKO, ARTO · 2015 to 2019
$3.7M
Fusing motor neuroscience and artificial intelligence to create next-generation neural prostheses.DP2NS127291 · NINDS · EMORY UNIVERSITY · PI PANDARINATH, CHETHAN · 2021 to 2024
$2.4M
NIDCD NIH HHS R01 DC014034NIDCD NIH HHS U01 DC017844NINDS NIH HHS DP2 NS127291NINDS NIH HHS U01 NS098968NINDS NIH HHS UH2 NS095548
6 · The paper itself

Abstract

How does the motor cortex combine simple movements (such as single finger flexion/extension) into complex movements (such hand gestures or playing piano)? Motor cortical activity was recorded using intracortical multi-electrode arrays in two people with tetraplegia as they attempted single, pairwise and higher order finger movements. Neural activity for simultaneous movements was largely aligned with linear summation of corresponding single finger movement activities, with two violations. First, the neural activity was normalized, preventing a large magnitude with an increasing number of moving fingers. Second, the neural tuning direction of weakly represented fingers (e.g. middle) changed significantly as a result of the movement of other fingers. These deviations from linearity resulted in non-linear methods outperforming linear methods for neural decoding. Overall, simultaneous finger movements are thus represented by the combination of individual finger movements by pseudo-linear summation.

Identifiers

PMID37873182
PMCPMC10592742
OpenAlexW4387568649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.