Evidence map›Paper›PMID 37873177›Full record

ArticlebioRxiv : the preprint server for biology2023

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway.

Trayambak Pathak, J Cory Benson, Martin T Johnson, Ping Xin, Ahmed Emam Abdelnaby, Vonn Walter, Walter A Koltun, Gregory S Yochum, Nadine Hempel, Mohamed Trebak

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Trayambak PathakDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
J Cory BensonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Martin T JohnsonDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Ping XinDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Ahmed Emam AbdelnabyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Vonn WalterDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States.
Walter A KoltunDepartment of Surgery, Division of Colon and Rectal Surgery, The Pennsylvania State University College of Medicine, Hershey, United States.
Gregory S YochumDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, United States.
Nadine HempelUPMC Hillman Cancer Center. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Mohamed TrebakDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
University of Pittsburgh · USPennsylvania State University · USEmory University · USUPMC Hillman Cancer Center · US

Funding

Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancerR01CA242021 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HEMPEL, NADINE · 2020 to 2024
$1.8M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
Genes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471k
Store-operated Orai3 calcium channels in metabolism and obesityK99HL163403 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PATHAK, TRAYAMBAK · 2022 to 2023
$209k
NCI NIH HHS R01 CA242021NHLBI NIH HHS K99 HL163403NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NHLBI NIH HHS R35 HL150778NIA NIH HHS R21 AG050072
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) stores large amounts of calcium (Ca

Indexed as

ATF4cMyccolorectal cancerER Ca2+ER stressmetabolismmitochondriaPERKSERCA2STIM2

Identifiers

PMID37873177
PMCPMC10592933
OpenAlexW4387310879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.