Evidence map›Paper›PMID 37873171›Full record

ArticlebioRxiv : the preprint server for biology2024

Non-canonical activation of IRE1α during

Michael J McFadden, Mack B Reynolds, Britton C Michmerhuizen, Einar B Ólafsson, Faith M Anderson, Tracey L Schultz, Mary X D O'Riordan, Teresa R O'Meara

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michael J McFaddenDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0303-6968
Mack B ReynoldsDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8445-3749
Britton C MichmerhuizenDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0000-5997-9581
Einar B ÓlafssonDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3388-061X
Faith M AndersonDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8456-621X
Tracey L SchultzDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Mary X D O'RiordanDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6014-4637
Teresa R O'MearaDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8901-0154
University of Michigan · US

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
TRAINING PROGRAM IN CELL AND MOLECULAR DERMATOLOGYT32AR007197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES TILFORD ELDER, Sunny Y Wong · 1986 to 2026
$4.2M
Mitochondrial stress shapes host responses to bacterial infectionR01AI157384 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'RIORDAN, MARY · 2021 to 2025
$2.0M
Global analysis of circuitry governing fungal activation of host inflammationK22AI137299 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMEARA, TERESA R. · 2019 to 2021
$303k
NIAID NIH HHS K22 AI137299NIAID NIH HHS R01 AI157384NIAID NIH HHS T32 AI007528NIAMS NIH HHS T32 AR007197
6 · The paper itself

Abstract

While the canonical function of IRE1α is to detect misfolded proteins and activate the unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can also activate IRE1α, which modulates innate immunity and infection outcomes. However, how infection activates IRE1α and its associated inflammatory functions have not been fully elucidated. Recognition of microbe-associated molecular patterns can activate IRE1α, but it is unclear whether this depends on protein misfolding. Here, we report that a common and deadly fungal pathogen,

Identifiers

PMID37873171
PMCPMC10592910
OpenAlexW4387308158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.