Evidence map›Paper›PMID 37873088›Full record

ArticlebioRxiv : the preprint server for biology2024

A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota.

Joshua M Kirsch, Andrew J Hryckowian, Breck A Duerkop

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joshua M KirschDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, School of Medicine, Aurora, Colorado, 80045, USA.
Andrew J HryckowianDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, 53706, USA.
Breck A DuerkopDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, School of Medicine, Aurora, Colorado, 80045, USA.ORCID 0000-0003-4030-9822
University of Colorado Anschutz Medical Campus · USUniversity of Wisconsin–Madison · US

Funding

Mechanistic basis of bacteriophages for the decolonization of vancomycin resistant enterococci in the intestine.R01AI141479 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DUERKOP, BRECK A · 2018 to 2025
$4.4M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
From cells to communities: The multi-scale impacts of bacteriophages in the gut microbiomeR35GM150996 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Andrew John Hryckowian · 2023 to 2026
$1.6M
Expansion of enterococcal insertion sequence elements during bacteriophage infectionF31AI169976 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KIRSCH, JOSHUA M · 2022 to 2023
$69k
NIAID NIH HHS F31 AI169976NIAID NIH HHS R01 AI141479NIAID NIH HHS T32 AI052066NIGMS NIH HHS R35 GM150996
6 · The paper itself

Abstract

Insertion sequence (IS) elements are mobile genetic elements in bacterial genomes that support adaptation. We developed a database of IS elements coupled to a computational pipeline that identifies IS element insertions in the microbiota. We discovered that diverse IS elements insert into the genomes of intestinal bacteria regardless of human host lifestyle. These insertions target bacterial accessory genes that aid in their adaptation to unique environmental conditions. Using IS expansion in

Identifiers

PMID37873088
PMCPMC10592638
OpenAlexW4387500428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.