Evidence map›Paper›PMID 37872954›Full record

ReviewJournal of inflammation research2023

Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives.

Haoran Chen, Zhongyu Han, Yi Wang, Junyan Su, Yumeng Lin, Xuhua Cheng, Wen Liu, Jingyu He, Yiyue Fan, Liuyan Chen and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of inflammation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  17. Identification of ferroptosis-related genes and potential drugs in osteoarthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  18. Review
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  20. SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Haoran Chen *Department of Orthopaedics, Chengdu Xinhua Hospital, Chengdu, 610000, People's Republic of China.
Zhongyu Han *School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People's Republic of China.
Yi Wang *Department of Orthopaedics, Chengdu Xinhua Hospital, Chengdu, 610000, People's Republic of China.
Junyan SuDepartment of Orthopaedics, The First People's Hospital of Longquanyi District, Chengdu, 610000, People's Republic of China.
Yumeng LinSchool of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People's Republic of China.
Xuhua ChengDepartment of Orthopaedics, Chengdu Xinhua Hospital, Chengdu, 610000, People's Republic of China.
Wen LiuDepartment of Orthopaedics, Chengdu Xinhua Hospital, Chengdu, 610000, People's Republic of China.
Jingyu HeSichuan Judicial and Police Officers Professional College, Deyang, 618000, People's Republic of China.
Yiyue FanAffiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.
Liuyan ChenSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People's Republic of China.
Houdong ZuoDepartment of Orthopaedics, Chengdu Xinhua Hospital, Chengdu, 610000, People's Republic of China.
XinHua Hospital · CNChengdu University of Traditional Chinese Medicine · CNAffiliated Hospital of North Sichuan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis is characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. Ferroptosis is involved in a variety of physiological and pathological processes. Since its discovery, ferroptosis has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress and prospects, summarize the regulatory mechanisms of ferroptosis, and discuss the role of ferroptosis in the pathogenesis of bone-related diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), and osteosarcoma (OS), as well as its therapeutic potential.

Indexed as

bone-related diseasescell deathferroptosisiron accumulationlipid peroxidation

Identifiers

PMID37872954
PMCPMC10590556
OpenAlexW4387731327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.