Evidence map›Paper›PMID 37872891›Full record

ArticleDevice2023

A gravity-driven droplet fluidic point-of-care test.

Hamed Vahabi, Jason Liu, Yifan Dai, Daniel Y Joh, Rhett Britton, Jacob Heggestad, David Kinnamon, Satyam Rajput, Ashutosh Chilkoti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Device, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hamed VahabiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
Jason LiuDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
Yifan DaiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
Daniel Y JohDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
Rhett BrittonDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
Jacob HeggestadDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
David KinnamonDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
Satyam RajputDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705.

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
A Fully Integrated Point-of-Care Test for EbolaR01AI150888 · NIAID · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2020 to 2024
$3.4M
Multiplex point-of-care test for diagnosis, prognosis and serology of COVID19R01AI159992 · NIAID · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2021 to 2023
$1.5M
NIAID NIH HHS R01 AI150888NIAID NIH HHS R01 AI159992NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

We report a simple droplet fluidic point-of-care test (POCT) that uses gravity to manipulate the sequence, timing, and motion of droplets on a surface. To fabricate this POCT, we first developed a surface coating toolbox of nine different coatings with three levels of wettability and three levels of slipperiness that can be independently tailored. We then fabricated a device that has interconnected fluidic elements-pumps, flow resistors and flow guides-on a highly slippery solid surface to precisely control the timing and sequence of motion of multiple droplets and their interactions on the surface. We then used this device to carry out a multi-step enzymatic assay of a clinically relevant analyte-lactate dehydrogenase (LDH)-to demonstrate the application of this technology for point-of-care diagnosis.

Identifiers

PMID37872891
PMCPMC10588563

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.